SCHEMBL160300

SCHEMBL160300

O=C(O)CNC12CC3CC(CC(O)(C3)C1)C2

nearest known ligand 0.58

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 11/20 0.58
DPP8 Q6V1X1 6/20 0.53
DPP9 Q86TI2 5/20 0.53
FAP Q12884 1/20 0.53
GLMN Q92990 1/20 0.48
ALDH1A1 P00352 1/20 0.44
DPP7 Q9UHL4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15557000 0.88 DPP4 (0.49) DPP4DPP8DPP9FAPGLMN
SCHEMBL12735378 0.86 DPP4 (0.56) DPP4DPP8DPP9FAPGLMN
SCHEMBL21816870 0.85 DPP4 (0.48) DPP4DPP8DPP9FAPGLMN
SCHEMBL12354573 0.83 DPP4 (0.53) DPP4DPP8DPP9FAPGLMN
SCHEMBL158816 0.83 DPP4 (0.58) DPP4FAPALDH1A1DPP7
Hydrochloric Acid SCHEMBL27500984 0.81 DPP4 (0.56) DPP4FAPALDH1A1DPP7
SCHEMBL27974243 0.80 DPP4 (0.50) DPP4DPP8DPP9FAPGLMN
SCHEMBL1038132 0.80 DPP4 (0.73) DPP4DPP8DPP9FAPGLMN
SCHEMBL30730737 0.80 DPP4 (0.73) DPP4DPP8DPP9FAPGLMN
SCHEMBL2237495 0.79 DPP4 (0.49) DPP4DPP8DPP9FAPDPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122038330-A Phenylalanine dehydrogenase mutant and application thereof 天津科技大学 2026-05-15 CN claimed
CN-118813600-A Preparation and application of carrier-free co-immobilized phenylalanine dehydrogenase and formate dehydrogenase 天津科技大学 2024-10-22 CN claimed
US-9376694-B2 Method for preparing optically active amino acid using cosubstrate shuttling of transaminase INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2016-06-28 US claimed
US-20150284750-A1 METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACID USING COSUBSTRATE SHUTTLING OF TRANSAMINASE INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) 2015-10-08 US claimed
WO-2012118318-A2 MICROORGANISM FOR PRODUCING NON-NATURAL AMINO ACIDS, AND METHOD FOR PRODUCING NON-NATRUAL AMINO ACIDS USING SAME 이화여자대학교 산학협력단 (KR) 2012-09-07 WO claimed
WO-2011101861-A1 PROCESS FOR PREPARATION OF DPP-IV INHIBITORS MSN LABORATORIES LIMITED (IN) 2011-08-25 WO claimed
CN-122038330-A Phenylalanine dehydrogenase mutant and application thereof 天津科技大学 2026-05-15 CN disclosed
CN-119350222-A Industrial preparation method of saxagliptin 山东安弘制药有限公司 2025-01-24 CN disclosed
CN-118813600-A Preparation and application of carrier-free co-immobilized phenylalanine dehydrogenase and formate dehydrogenase 天津科技大学 2024-10-22 CN disclosed
CN-116253804-A Self-assembled proteins of phenylalanine dehydrogenase and formate dehydrogenase and uses thereof 天津科技大学 2023-06-13 CN disclosed
CN-109761876-B Preparation method of medicine saxagliptin for treating diabetes 深圳市第二人民医院 2021-11-16 CN disclosed
CN-111892478-A Synthetic method of saxagliptin intermediate 陈华荣 2020-11-06 CN disclosed
CN-104817476-B Method for preparing unnatural amino acid 重庆医科大学 2020-09-11 CN disclosed
CN-103965065-A Saxagliptin intermediate, its salt, preparation method and application SHANGSHAI SHYNDEC PHARMACEUTICAL CO LTD 2014-08-06 CN disclosed
WO-2014007588-A1 METHOD FOR PREPARING OPTICALLY ACTIVE AMINO ACID BY USING MATRIX CIRCULATION OF TRANSAMINASE 연세대학교 산학협력단 (KR) 2014-01-09 WO disclosed
EP-2611770-A1 PROCESS FOR THE REDUCTIVE AMINATION OF -KETO CARBOXYLIC ACIDS Sandoz AG (CH) 2013-07-10 EP disclosed
WO-2012118318-A2 MICROORGANISM FOR PRODUCING NON-NATURAL AMINO ACIDS, AND METHOD FOR PRODUCING NON-NATRUAL AMINO ACIDS USING SAME 이화여자대학교 산학협력단 (KR) 2012-09-07 WO disclosed
WO-2012028721-A1 PROCESS FOR THE REDUCTIVE AMINATION OF α-KETO CARBOXYLIC ACIDS SANDOZ AG (CH) 2012-03-08 WO disclosed
WO-2011101861-A1 PROCESS FOR PREPARATION OF DPP-IV INHIBITORS MSN LABORATORIES LIMITED (IN) 2011-08-25 WO disclosed
WO-2011101861-A1 PROCESS FOR PREPARATION OF DPP-IV INHIBITORS MSN LABORATORIES LIMITED (IN) 2011-08-25 WO disclosed