SCHEMBL1603399

SCHEMBL1603399

CCC1=C(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)C(CCC(=O)O)=C4C)c(C)c3CC.[Cd]

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.62
TDP1 Q9NUW8 3/20 0.62
MEN1 O00255 2/20 0.62
MAPT P10636 2/20 0.62
THRB P10828 2/20 0.62
MAPK1 P28482 2/20 0.62
KMT2A Q03164 2/20 0.62
APEX1 P27695 2/20 0.62
USP2 O75604 1/20 0.62
LMNA P02545 1/20 0.62
CYP1A2 P05177 1/20 0.62
POLB P06746 1/20 0.62
CYP2D6 P10635 1/20 0.62
HSPD1 P10809 1/20 0.62
CYP2C9 P11712 1/20 0.62
HPGD P15428 1/20 0.62
ALOX15 P16050 1/20 0.62
NFKB1 P19838 1/20 0.62
CYP2C19 P33261 1/20 0.62
RECQL P46063 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9609762 0.99 HSD17B10 (0.63) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL5447002 0.99 HSD17B10 (0.63) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL314687 0.99 HSD17B10 (0.63) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL6413992 0.99 HSD17B10 (0.63) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL1603867 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL1602877 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL1603405 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL1603809 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL21051915 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB
SCHEMBL1603375 0.98 HSD17B10 (0.62) HSD17B10TDP1MEN1MAPTTHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11078220-B2 High-purity large-scale preparation of stannsoporfin Mallinckrodt Hospital Products IP Limited (IE) 2021-08-03 US disclosed
US-20200255458-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN MALLINCKRODT LLC 2020-08-13 US disclosed
US-10662209-B2 High-purity large-scale preparation of stannsoporfin Mallinckrodt Hospital Products IP Limited (IE) 2020-05-26 US disclosed
US-20190202846-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SpecGx LLC 2019-07-04 US disclosed
US-10273255-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2019-04-30 US disclosed
US-20180134735-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN MALLINCKRODT LLC 2018-05-17 US disclosed
US-9902745-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2018-02-27 US disclosed
US-20170073362-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN VTESSE LLC 2017-03-16 US disclosed
US-9517239-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2016-12-13 US disclosed
EP-2992886-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN InfaCare Pharmaceutical Corporation (US) 2016-03-09 EP disclosed
US-20160000802-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) 2016-01-07 US disclosed
US-9107927-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2015-08-18 US disclosed
US-20150051184-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SUCAMPO PHARMA AMERICAS LLC 2015-02-19 US disclosed
US-8835416-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2014-09-16 US disclosed
US-20140005380-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN INFACARE PHARMACEUTICAL CORPORATION (US) 2014-01-02 US disclosed
US-8530458-B2 High-purity large-scale preparation of stannsoporfin INFACARE PHARMACEUTICAL CORPORATION (US) 2013-09-10 US disclosed
EP-2384756-A2 High-purity large-scale preparation of stannsoporfin InfaCare Pharmaceutical Corporation (US) 2011-11-09 EP disclosed
US-7960371-B2 reduction of hemin with hydrogenation catalysts, in the presence of hydrogen, then heating to remove iron and form mesoporphyrin, and reacting with tin oxide top form pure tin mesoporphyrin; inhibitor of heme oxygenase, used in the treatment of infant jaundice or hyperbilirubinemia; liver disorders INFACARE PHARMACEUTICAL CORPORATION (US) 2011-06-14 US disclosed
US-20110082292-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN OCERA THERAPEUTICS LLC 2011-04-07 US disclosed
US-20080125585-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN STRATATECH CORPORATION 2008-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140005380-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20180134735-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-10662209-B2 High-purity large-scale preparation of stannsoporfin SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20080125585-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-10273255-B2 High-purity large-scale preparation of stannsoporfin SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20160000802-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20200255458-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20170073362-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-11078220-B2 High-purity large-scale preparation of stannsoporfin SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20190202846-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20110082292-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885
US-20150051184-A1 HIGH-PURITY LARGE-SCALE PREPARATION OF STANNSOPORFIN SNRPF, HNRNPF, NUP188 HSD17B10 2207/4885TDP1 3387/4885MEN1 422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.