Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31318073 | 1.00 | GAA (0.46) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL16033677 | 1.00 | GAA (0.46) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL31681701 | 1.00 | GAA (0.46) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL16033675 | 1.00 | GAA (0.46) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL19933891 | 0.88 | CHRM1 (0.46) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL31318072 | 0.85 | CHRM1 (0.40) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL31318070 | 0.85 | CHRM1 (0.40) | GAACHRM1CHRM2CHRM5CHRM3 | |
| SCHEMBL19933740 | 0.83 | THRA (0.39) | FFAR4THRATHRB | |
| SCHEMBL16035083 | 0.81 | TSHR (0.45) | TSHR | |
| SCHEMBL7813526 | 0.74 | KMT2A (0.50) | GAALMNATSHRKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970090-B1 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND TOTAL SYNTHESIS THEREOF | UNIV MACAU (CN) | 2019-05-08 | — | — | EP | claimed |
| US-10011555-B2 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (CN) | 2018-07-03 | — | — | US | claimed |
| US-20180065912-A1 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (MO) | 2018-03-08 | — | — | US | claimed |
| US-9475749-B2 | Anti-neurodegenerative natural compound isolated from alpiniae oxyphyllae fructose and their total synthesis | UNIVERSITY OF MACAU (CN) | 2016-10-25 | — | — | US | claimed |
| EP-2970090-A2 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND TOTAL SYNTHESIS THEIROF | University of Macau (CN) | 2016-01-20 | — | — | EP | claimed |
| US-20140275236-A1 | Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis | UNIVERSITY OF MACAU (MO) | 2014-09-18 | — | — | US | claimed |
| WO-2014141169-A2 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND THEIR TOTAL SYNTHESIS | UNIVERSITY OF MACAU (CN) | 2014-09-18 | — | — | WO | claimed |
| EP-2970090-B1 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND TOTAL SYNTHESIS THEREOF | UNIV MACAU (CN) | 2019-05-08 | — | — | EP | disclosed |
| US-10011555-B2 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (CN) | 2018-07-03 | — | — | US | disclosed |
| US-10011555-B2 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (CN) | 2018-07-03 | — | — | US | disclosed |
| US-10011555-B2 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (CN) | 2018-07-03 | — | — | US | disclosed |
| US-20180065912-A1 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (MO) | 2018-03-08 | — | — | US | disclosed |
| US-20180065912-A1 | Methods of treating Parkinson's disease | UNIVERSITY OF MACAU (MO) | 2018-03-08 | — | — | US | disclosed |
| US-9475749-B2 | Anti-neurodegenerative natural compound isolated from alpiniae oxyphyllae fructose and their total synthesis | UNIVERSITY OF MACAU (CN) | 2016-10-25 | — | — | US | disclosed |
| EP-2970090-A2 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND TOTAL SYNTHESIS THEIROF | University of Macau (CN) | 2016-01-20 | — | — | EP | disclosed |
| US-20140275236-A1 | Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis | UNIVERSITY OF MACAU (MO) | 2014-09-18 | — | — | US | disclosed |
| US-20140275236-A1 | Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis | UNIVERSITY OF MACAU (MO) | 2014-09-18 | — | — | US | disclosed |
| US-20140275236-A1 | Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis | UNIVERSITY OF MACAU (MO) | 2014-09-18 | — | — | US | disclosed |
| WO-2014141169-A2 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND THEIR TOTAL SYNTHESIS | UNIVERSITY OF MACAU (CN) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014141169-A2 | NOVEL ANTI-NEURODEGENERATIVE NATURAL COMPOUNDS ISOLATED FROM ALPINIAE OXYPHYLLAE FRUCTUS AND THEIR TOTAL SYNTHESIS | UNIVERSITY OF MACAU (CN) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275236-A1 | Novel anti-neurodegenerative natural compounds isolated from Alpiniae Oxyphyllae Fructus and their total synthesis | SNCA, PARK7, NLN | GAA 194/4885CHRM1 2536/4885CHRM2 2846/4885 |
| US-10011555-B2 | Methods of treating Parkinson's disease | PARK7, SNCA, NLN | GAA 77/4885CHRM1 1943/4885CHRM2 1818/4885 |
| US-20180065912-A1 | Methods of treating Parkinson's disease | PARK7, SNCA, NLN | GAA 77/4885CHRM1 1943/4885CHRM2 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.