SCHEMBL16036244

SCHEMBL16036244

CC1c2nnn(-c3ncc(F)cn3)c2CCN1C(=O)OC(C)(C)C

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 20/20 0.59
CYP2C8 P10632 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16036245 1.00 P2RX7 (0.59) P2RX7CYP2C8
SCHEMBL28670732 0.84 P2RX7 (0.65) P2RX7CYP2C8
SCHEMBL16035401 0.79 P2RX7 (0.62) P2RX7
SCHEMBL16035402 0.79 P2RX7 (0.62) P2RX7
SCHEMBL20194820 0.75 P2RX7 (0.58) P2RX7CYP2C8
SCHEMBL16037288 0.75 P2RX7 (0.75) P2RX7CYP2C8
SCHEMBL16035419 0.75 P2RX7 (1.00) P2RX7CYP2C8
SCHEMBL16036004 0.75 P2RX7 (1.00) P2RX7CYP2C8
SCHEMBL16036879 0.74 P2RX7 (1.00) P2RX7CYP2C8
SCHEMBL16036382 0.74 P2RX7 (0.79) P2RX7CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
US-20200325138-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-10-15 US disclosed
US-10703749-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2020-07-07 US disclosed
EP-3495365-A1 P2X7 MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
US-20190092770-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2019-03-28 US disclosed
US-10150765-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2018-12-11 US disclosed
EP-3239151-A1 P2X7 MODULATORS Janssen Pharmaceutica NV (BE) 2017-11-01 EP disclosed
EP-2970267-B1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2017-05-24 EP disclosed
US-20160376271-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV 2016-12-29 US disclosed
US-9464084-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2016-10-11 US disclosed
US-20160039809-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2016-02-11 US disclosed
EP-2970267-A1 P2X7 MODULATORS Janssen Pharmaceutica, N.V. (BE) 2016-01-20 EP disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325138-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-10150765-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20160376271-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20190092770-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20160039809-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RX5 P2RX7 2/4885CYP2C8 1040/4885
US-20150322062-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-10703749-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 P2RX7 2/4885CYP2C8 1097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.