SCHEMBL16036764

SCHEMBL16036764

CCc1nc2cnccc2n1-c1ccccc1

nearest known ligand 0.70

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RPS6KA5 O75582 2/20 0.52
ATM Q13315 1/20 0.50
ALDH1A1 P00352 1/20 0.45
FGFR1 P11362 1/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.45
PDE10A Q9Y233 5/20 0.44
CYP1A2 P05177 1/20 0.44
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
MAPT P10636 1/20 0.42
CASP1 P29466 1/20 0.42
RAB9A P51151 1/20 0.42
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
PABPC1 P11940 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7774775 0.84 RPS6KA5 (0.46) RPS6KA5ATMALDH1A1NPC1TP53
SCHEMBL541105 0.84 CETP (0.48) RPS6KA5ATMMAPK1PDE10APOLB
SCHEMBL540767 0.83 MAPK1 (0.67) RPS6KA5ATMALDH1A1MAPK1HTT
SCHEMBL762447 0.82 MAPK1 (0.66) ALDH1A1MAPK1HTTPDE10ACYP1A2
SCHEMBL9727037 0.82 CYP19A1 (0.46) RPS6KA5
SCHEMBL10247453 0.78 ATM (0.65) RPS6KA5ATMALDH1A1FGFR1HTT
SCHEMBL25112562 0.77 PDE10A (0.63) ALDH1A1FGFR1PDE10A
SCHEMBL19851076 0.76 RPS6KA5 (0.52) RPS6KA5ATMALDH1A1FGFR1MAPK1
SCHEMBL16332838 0.76 RPS6KA5 (0.52) RPS6KA5ATMALDH1A1FGFR1MAPK1
SCHEMBL16054504 0.76 RPS6KA5 (0.52) RPS6KA5ATMALDH1A1FGFR1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
CN-110003200-B P2X7 modulators 詹森药业有限公司 2021-11-26 CN disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-20150322062-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 RPS6KA5 1771/4885ATM 4120/4885ALDH1A1 1628/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.