Lerociclib

Lerociclib

SCHEMBL16036885

CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 20/20 1.00
CDK4 P11802 16/20 1.00
CCND1 P24385 16/20 1.00
CCND3 P30281 3/20 1.00
CDK6 Q00534 3/20 1.00
CCNT1 O60563 2/20 1.00
CDK9 P50750 2/20 1.00
TTK P33981 1/20 1.00
FLT3 P36888 1/20 1.00
CCNH P51946 1/20 1.00
NEK10 Q6ZWH5 1/20 1.00
ULK2 Q8IYT8 1/20 1.00
NUAK2 Q9H093 1/20 1.00
CCNE1 P24864 9/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lerociclib SCHEMBL22832157 1.00 CDK2 (1.00) CDK2CDK4CCND1CCND3CDK6
Lerociclib SCHEMBL30175009 1.00 CDK2 (1.00) CDK2CDK4CCND1CCND3CDK6
Lerociclib SCHEMBL29409995 0.99 CDK2 (0.98) CDK2CDK4CCND1CCND3CDK6
Lerociclib SCHEMBL23711495 0.99 CDK2 (0.98) CDK2CDK4CCND1CCND3CDK6
Lerociclib SCHEMBL29409994 0.99 CDK2 (0.98) CDK2CDK4CCND1CCND3CDK6
SCHEMBL15249273 0.99 CDK2 (1.00) CDK2CDK4CCND1CCND3CDK6
SCHEMBL24413774 0.92 CDK2 (0.85) CDK2CDK4CCND1CCND3CDK6
SCHEMBL20980212 0.92 CDK2 (0.87) CDK2CDK4CCND1CCND3CDK6
Trilaciclib SCHEMBL29356370 0.91 CDK2 (1.00) CDK2CDK4CCND1CCND3CDK6
Trilaciclib SCHEMBL29763763 0.91 CDK2 (1.00) CDK2CDK4CCND1CCND3CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144778-A1 REGIMENS OF ESTROGEN RECEPTOR ANTAGONISTS OLEMA PHARMACEUTICALS, INC. (US) 2026-05-28 US claimed
WO-2026103886-A1 PHARMACEUTICAL COMPOSITION, KIT AND USE THEREOF 浙江扬厉医药技术有限公司 2026-05-21 WO claimed
WO-2026101937-A1 COMPOSITIONS COMPRISING (Z)-ENDOXIFEN AND A CDK4/6 INHIBITOR AND METHODS OF USE THEREOF ATOSSA THERAPEUTICS, INC. (US) 2026-05-15 WO claimed
US-20260103461-A1 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF OLEMA PHARMACEUTICALS INC (US) 2026-04-16 US claimed
EP-4704841-A1 IMLUNESTRANT OR SALTS THEREOF FOR USE IN TREATING AND PREVENTING CENTRAL NERVOUS SYSTEM (CNS) METASTASES IN SUBJECTS HAVING ER+ BREAST CANCER Eli Lilly and Company (US) 2026-03-11 EP claimed
EP-4698175-A1 LYSINE ACETYLTRANSFERASE 6A (KAT6A) INHIBITOR, COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-02-25 EP claimed
EP-4683635-A1 USES OF A CHECKPOINT KINASE 1 (CHK1) INHIBITOR Boundless Bio, Inc. (US) 2026-01-28 EP claimed
EP-4680226-A2 ACYLSULFONAMIDE KAT6A INHIBITORS Olema Pharmaceuticals, Inc. (US) 2026-01-21 EP claimed
EP-4653019-A1 ANTI-HER2 ANTIBODY-DRUG CONJUGATE FOR TREATING BREAST CANCER Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) 2025-11-26 EP claimed
US-20250352531-A1 Dosage Regimen for the Treatment of Cancer ASTRAZENECA AB (SE) 2025-11-20 US claimed
EP-3973964-A1 QUINOLINE DERIVATIVE USED FOR COMBINATION TREATMENT OF SMALL CELL LUNG CANCER Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2022-03-30 EP claimed
EP-3973963-A1 QUINOLINE DERIVATIVES FOR TREATMENT OF HEAD AND NECK CANCER Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2022-03-30 EP claimed
EP-3967310-A1 QUINOLINE DERIVATIVE USED FOR SOFT TISSUE SARCOMA COMBINATION THERAPY CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2022-03-16 EP claimed
US-11261193-B2 Morphic forms of G1T38 and methods of manufacture thereof GI Therapeutics, Inc. (US) 2022-03-01 US claimed
US-20220054488-A1 COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER ICAHN SCHOOL MED MOUNT SINAI (US) 2022-02-24 US claimed
EP-3957631-A1 QUINOLINE COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR TREATING EWING'S SARCOMA Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) 2022-02-23 EP claimed
US-20220040324-A1 COMBINATION OF ANTIBODY-DRUG CONJUGATE AND KINASE INHIBITOR DAIICHI SANKYO COMPANY, LIMITED (JP) 2022-02-10 US claimed
WO-2022017524-A1 PYRIDONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 深圳晶泰科技有限公司 2022-01-27 WO claimed
WO-2021226263-A1 COMBINATIONS RECURIUM IP HOLDINGS, LLC (US) 2021-11-11 WO claimed
US-20200123168-A1 MORPHIC FORMS OF G1T38 AND METHODS OF MANUFACTURE THEREOF G1 THERAPEUTICS, INC. (US) 2020-04-23 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200123168-A1 MORPHIC FORMS OF G1T38 AND METHODS OF MANUFACTURE THEREOF H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RAB8A, UGT1A8 CDK2 1521/4885CDK4 2034/4885CCND1 362/4885
US-20260103461-A1 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF ESRRA, GPER1, ESR2 CDK2 1041/4885CDK4 2226/4885CCND1 2445/4885
US-20220054488-A1 COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER CDK4, CDK6, CDK2 CDK2 3/4885CDK4 1/4885CCND1 26/4885
US-20220040324-A1 COMBINATION OF ANTIBODY-DRUG CONJUGATE AND KINASE INHIBITOR WEE1, ERBB3, ERBB2 CDK2 30/4885CDK4 50/4885CCND1 356/4885
US-20250352531-A1 Dosage Regimen for the Treatment of Cancer CDK4, CDK3, CDK8 CDK2 8/4885CDK4 1/4885CCND1 22/4885
US-11261193-B2 Morphic forms of G1T38 and methods of manufacture thereof H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RAB8A, COG8 CDK2 3293/4885CDK4 3334/4885CCND1 687/4885
US-20260144778-A1 REGIMENS OF ESTROGEN RECEPTOR ANTAGONISTS ESR1, ESR2, PGR CDK2 25/4885CDK4 4/4885CCND1 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.