COG8 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to COG8 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacement Therapy	PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
PBA Use for Treatment of ATF6-/- Patients	EARLY_PHASE1	SUSPENDED
Glutamine Supplementation in People With Immune Dysregulation	EARLY_PHASE1	WITHDRAWN
Study of the Pathophysiological Mechanisms Involved in Bleeding Events	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM)	nan	COMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios	nan	COMPLETED
Investigations Into ISCU Myopathy or Iron Sulfur Scaffold U Protein Myopathy	nan	COMPLETED
Pediatric Evaluation and Registry for Liver Cholestasis in Canada	nan	RECRUITING
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing	nan	COMPLETED
Immunological Profile and Clinical Characteristics of Children Diagnosed With Chronic Granulomatous Disease	nan	UNKNOWN
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Role of Polymorphisms in the IL-1 Gene Cluster	nan	COMPLETED
Clinical, Cellular, and Molecular Investigation Into Oculocutaneous Albinism	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Natural History Study of GEMIN-5 Related Neurodevelopmental Disorder	nan	RECRUITING
Exome Analysis in Hearing Impaired Patients	nan	UNKNOWN
Protein Synthesis in the Brain of Patients With Fragile X Syndrome	nan	COMPLETED
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance	nan	COMPLETED
Defining Clinical Endpoints in Limb Girdle Muscular Dystrophy (LGMD)	nan	COMPLETED
Genetic Analysis of Gray Platelet Syndrome	nan	COMPLETED
Immune Cell Response to Stimuli	nan	RECRUITING
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a COG8 binder may also engage these)

Protein	Name	Similarity
Q9JJA2	—	1.000	Q9JJA2 →
Q2TBH9	—	0.999	Q2TBH9 →
A4IF89	—	0.989	A4IF89 →
Q9VKH0	—	0.988	Q9VKH0 →
Q6PGF7	—	0.988	Q6PGF7 →
Q8IYI6	—	0.987	Q8IYI6 →
Q921L5	—	0.987	Q921L5 →
Q5ZJ43	—	0.986	Q5ZJ43 →
Q8CI04	—	0.986	Q8CI04 →
COG7	Conserved oligomeric Golgi complex subunit 7	0.985	landscape →
O54924	—	0.985	O54924 →
Q6NMI3	—	0.985	Q6NMI3 →
COG2	Conserved oligomeric Golgi complex subunit 2	0.984	landscape →
Q3T1G7	—	0.983	Q3T1G7 →
Q8MSY4	—	0.982	Q8MSY4 →
F4HQ84	—	0.982	F4HQ84 →
Q5U247	—	0.981	Q5U247 →
COG5	Conserved oligomeric Golgi complex subunit 5	0.981	landscape →
Q0V8C2	—	0.981	Q0V8C2 →
Q29N70	—	0.981	Q29N70 →
Q961G1	—	0.980	Q961G1 →
Q8K2Z4	—	0.980	Q8K2Z4 →
COG3	Conserved oligomeric Golgi complex subunit 3	0.980	landscape →
F4JHH5	—	0.980	F4JHH5 →
A2VDR8	—	0.980	A2VDR8 →
Q6ZPE2	—	0.980	Q6ZPE2 →
D3Z8X7	—	0.979	D3Z8X7 →
Q3UM29	—	0.979	Q3UM29 →
Q3TBD2	—	0.979	Q3TBD2 →
COG1	Conserved oligomeric Golgi complex subunit 1	0.979	landscape →