Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604898 | 0.99 | ELANE (0.78) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL1604290 | 0.97 | ELANE (0.77) | ELANENPSR1CCR1KDM4EMEN1 | |
| Acetic Acid SCHEMBL1604206 | 0.97 | ELANE (0.74) | ELANENPSR1CCR1KDM4EMEN1 | |
| Iodide SCHEMBL1603024 | 0.96 | ELANE (0.76) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL1604508 | 0.95 | ELANE (0.81) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL1603074 | 0.93 | ELANE (0.69) | ELANENPSR1KDM4E | |
| Acetic Acid SCHEMBL1603712 | 0.92 | ELANE (0.76) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL14922185 | 0.92 | ELANE (0.81) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL14922184 | 0.91 | ELANE (0.80) | ELANENPSR1CCR1KDM4EMEN1 | |
| SCHEMBL1604172 | 0.90 | ELANE (0.77) | ELANENPSR1CCR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436024-B2 | 2-pyridone compounds | ASTRAZENECA AB (GB) | 2013-05-07 | — | — | US | disclosed |
| US-20110082155-A1 | Novel 2-Pyridone Compounds | ASTRAZENECA AB (SE) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082155-A1 | Novel 2-Pyridone Compounds | SERPINB1, ELANE, EPX | ELANE 2/4885NPSR1 1270/4885CCR1 226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.