SCHEMBL160403

SCHEMBL160403

COC(=O)CCc1ncc(-c2ccc(NC(=O)c3ccc(C(C)(C)C)cc3)cc2)s1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.56
LMNA P02545 1/20 0.53
MAPT P10636 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
TRPV1 Q8NER1 7/20 0.50
TP53 P04637 1/20 0.48
NR1H4 Q96RI1 2/20 0.47
HDAC3 O15379 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL162497 0.94 DGAT1 (0.54) DGAT1LMNAMAPTSMN1; SMN2TRPV1
SCHEMBL161479 0.90 NR1H4 (0.61) DGAT1TRPV1NR1H4HDAC3HDAC11
SCHEMBL163250 0.86 DGAT1 (0.54) DGAT1LMNAMAPTSMN1; SMN2TRPV1
SCHEMBL161347 0.86 DGAT1 (0.54) DGAT1LMNAMAPTSMN1; SMN2TRPV1
SCHEMBL162665 0.86 NR1H4 (0.62) DGAT1TRPV1NR1H4HDAC3HDAC11
SCHEMBL158605 0.85 SMN1; SMN2 (0.53) LMNAMAPTSMN1; SMN2TP53NR1H4
SCHEMBL160317 0.84 TRPV1 (0.48) DGAT1SMN1; SMN2TRPV1
SCHEMBL161964 0.84 DGAT1 (0.56) DGAT1LMNAMAPTSMN1; SMN2TRPV1
SCHEMBL161164 0.84 DGAT1 (0.58) DGAT1TRPV1NR1H4HDAC3HDAC11
SCHEMBL163011 0.83 PLAU (0.55) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3060043-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS CORTEVA AGRISCIENCE LLC (US) 2025-11-26 EP claimed
EP-3578542-B1 COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-11-12 EP claimed
EP-3578543-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-08-20 EP claimed
EP-3578541-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY, AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-05-28 EP claimed
US-20240188569-A1 NEW YEAST STRAIN AND ITS USES FOR THE CONTROL OF PHYTOPATHOGENS AGROVENTURES LLC (US) 2024-06-13 US claimed
EP-4323496-A1 NEW YEAST STRAIN AND ITS USES FOR THE CONTROL OF PHYTOPATHOGENS AGROVENTURES S.R.L. (IT) 2024-02-21 EP claimed
WO-2023212494-A2 PREDICTIVE PESTICIDE RESISTANCE INFORMATION GENERATION AND USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2023-11-02 WO claimed
EP-3614845-B1 FUNGICIDAL COMBINATIONS UPL LTD (IN) 2023-11-01 EP claimed
EP-4255175-A1 PREDICTIVE PESTICIDE RESISTANCE MAP GENERATION AND USE Pioneer Hi-Bred International, Inc. (US) 2023-10-11 EP claimed
WO-2022219505-A1 NEW YEAST STRAIN AND ITS USES FOR THE CONTROL OF PHYTOPATHOGENS AGROVENTURES S.R.L. (IT) 2022-10-20 WO claimed
US-20120195974-A1 CONTROLLING MEALYBUGS DOW AGROSCIENCES LLC (US) 2012-08-02 US claimed
WO-2012103393-A2 CONTROLLING MEALYBUGS DOW AGROSCIENCES LLC (US) 2012-08-02 WO claimed
WO-2012061290-A2 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2012-05-10 WO claimed
WO-2012061288-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2012-05-10 WO claimed
US-20120110701-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2012-05-03 US claimed
US-20120110702-A1 Pesticidal Compositions and Processes Related Thereto CORTEVA AGRISCIENCE LLC 2012-05-03 US claimed
WO-2012029032-A2 HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS PIRAMAL LIFE SCIENCES LIMITED (IN) 2012-03-08 WO claimed
EP-2323844-A1 GELATINOUS ELASTOMER COMPOSITIONS Silipos Inc. (US) 2011-05-25 EP claimed
WO-2010030824-A1 GELATINOUS ELASTOMER COMPOSITIONS SILIPOS, INC. (US) 2010-03-18 WO claimed
US-20100063008-A1 GELATINOUS ELASTOMER COMPOSITIONS SILIPOS, INC. (US) 2010-03-11 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120110701-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, AGPS, DDT DGAT1 1074/4885LMNA 2782/4885MAPT 3668/4885
US-20120110702-A1 Pesticidal Compositions and Processes Related Thereto ACHE, DDT, PTMS DGAT1 1025/4885LMNA 2810/4885MAPT 3415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.