Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 16/20 | 0.56 |
| ▸ | SLC46A1 | Q96NT5 | 13/20 | 0.56 |
| ▸ | FOLR1 | P15328 | 12/20 | 0.56 |
| ▸ | FOLR2 | P14207 | 9/20 | 0.56 |
| ▸ | SLC19A1 | P41440 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1604525 | 0.91 | GART (0.51) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1604571 | 0.85 | GART (0.53) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1604415 | 0.85 | SLC46A1 (0.72) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1605557 | 0.85 | FOLR1 (0.53) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1604393 | 0.85 | GART (0.61) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL3159760 | 0.85 | FOLR1 (0.72) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1604705 | 0.85 | SLC46A1 (0.72) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1605457 | 0.84 | GART (0.77) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL1605452 | 0.84 | GART (0.77) | GARTSLC46A1FOLR1FOLR2SLC19A1 | |
| SCHEMBL3165312 | 0.84 | GART (0.72) | GARTSLC46A1FOLR1FOLR2SLC19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082158-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE AND/OR OTHER FOLATE METABOLIZING ENZYMES INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, FOLR2, FOLR1 | GART 22/4885SLC46A1 1/4885FOLR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.