SCHEMBL16045348

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL16045415	1.00	KMT2A (0.46)	KMT2AKDM4ELMNAGRM1HTT
	SCHEMBL16044197	0.94	GABRA1 (0.38)	KMT2AKDM4ELMNAGRM1GABRA1
	Trifluoroacetic Acid SCHEMBL18759418	0.90	PDE10A (0.44)	KMT2AKDM4ELMNAGRM1HTT
	Trifluoroacetic Acid SCHEMBL18759441	0.90	PDE10A (0.44)	KMT2AKDM4ELMNAGRM1HTT
	SCHEMBL16044246	0.89	BRAF (0.39)	KMT2AKDM4EGABRA1GABRG2GABRB3
	SCHEMBL16047506	0.89	GRM1 (0.41)	LMNAGRM1GAAALDH1A1GABRA1
	SCHEMBL16044266	0.89	MAPK14 (0.50)	GRM1GABRA1GABRG2GABRB3GABRA5
	SCHEMBL16045854	0.89	BRAF (0.39)	KMT2AKDM4EGABRA1GABRG2GABRB3
	SCHEMBL16046501	0.89	MAPK14 (0.50)	GRM1GABRA1GABRG2GABRB3GABRA5
	SCHEMBL16044000	0.89	GRM1 (0.43)	KMT2AKDM4ELMNAGRM1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.