Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18759418 | 1.00 | PDE10A (0.44) | PDE10AKDM4EKMT2AGRM1LMNA | |
| Trifluoroacetic Acid SCHEMBL18759421 | 0.92 | PDE10A (0.44) | PDE10AKDM4EKMT2AHPGDSLC22A12 | |
| Trifluoroacetic Acid SCHEMBL18759474 | 0.92 | PDE10A (0.44) | PDE10AGRM1LMNAHPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL18759443 | 0.92 | PDE10A (0.44) | PDE10AKDM4EGRM1SMN1; SMN2SLC22A12 | |
| Trifluoroacetic Acid SCHEMBL18759412 | 0.92 | PDE10A (0.44) | PDE10AKDM4EKMT2AHPGDSLC22A12 | |
| Trifluoroacetic Acid SCHEMBL18759465 | 0.92 | PDE10A (0.44) | PDE10AHPGDSLC22A12HTTKDR | |
| Trifluoroacetic Acid SCHEMBL18759406 | 0.91 | PDE10A (0.45) | PDE10AGRM1LMNASLC22A12HTT | |
| SCHEMBL16045415 | 0.90 | KMT2A (0.46) | KDM4EKMT2AGRM1LMNAHPGD | |
| SCHEMBL16045348 | 0.90 | KMT2A (0.46) | KDM4EKMT2AGRM1LMNAHPGD | |
| Trifluoroacetic Acid SCHEMBL18759433 | 0.89 | PDE10A (0.42) | PDE10AKMT2AHPGDSMN1; SMN2SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970328-B1 | NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | ABBVIE DEUTSCHLAND (DE) | 2017-04-26 | — | — | EP | disclosed |