Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16045207 | 0.92 | ALDH1A1 (0.50) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| Benzoic Acid SCHEMBL561535 | 0.89 | MAPK1 (0.46) | MAPK1RARBTSHRDAONAPRT | |
| Benzoic Acid SCHEMBL4577223 | 0.89 | MAPK1 (0.46) | MAPK1RARBTSHRDAONAPRT | |
| Benzoic Acid SCHEMBL29415301 | 0.84 | MAPK1 (0.40) | MAPK1LPAR1LPAR5RARBTSHR | |
| Benzoyl Formic Acid SCHEMBL16045154 | 0.83 | MAPK1 (0.41) | ALDH1A1MAPK1RARBTSHRDAO | |
| Benzoic Acid SCHEMBL27644506 | 0.83 | MAPK1 (0.41) | MAPK1LPAR1LPAR5RARBTSHR | |
| Benzoic Acid SCHEMBL29006857 | 0.83 | MAPK1 (0.41) | MAPK1LPAR1LPAR5RARBTSHR | |
| Benzoic Acid SCHEMBL16047662 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MAPK1LPAR1LPAR5TSHR | |
| Benzoic Acid SCHEMBL29006820 | 0.81 | MAPK1 (0.40) | ALDH1A1MAPK1RARBTSHRDAO | |
| Benzoic Acid SCHEMBL16046325 | 0.80 | TAS2R14 (0.40) | ALDH1A1MAPK1RARBTSHRDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969201-B1 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | FORMOSA PLASTICS CORP USA (US) | 2022-05-04 | — | — | EP | disclosed |
| US-9790291-B2 | Non-phthalate compounds as electron donors for polyolefin catalysts | FORMOSA PLASTICS CORPORATION, USA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20140275456-A1 | NON-PHTHALATE COMPOUNDS AS ELECTRON DONORS FOR POLYOLEFIN CATALYSTS | FORMOSA PLASTICS CORPORATION, USA (US) | 2014-09-18 | — | — | US | disclosed |