Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049887 | 0.84 | NOTUM (0.47) | LMNAKMT2AMAPTTSHRL3MBTL1 | |
| SCHEMBL25980852 | 0.83 | LMNA (0.52) | LMNANCOA1NCOA3KMT2AMEN1 | |
| SCHEMBL731013 | 0.82 | LMNA (0.50) | LMNANCOA1NCOA3KMT2AMEN1 | |
| SCHEMBL6601501 | 0.78 | MAPT (0.59) | LMNANCOA1NCOA3KMT2AMEN1 | |
| SCHEMBL733132 | 0.78 | TSHR (0.50) | LMNANCOA1NCOA3KMT2AMEN1 | |
| SCHEMBL732996 | 0.78 | TSHR (0.50) | LMNANCOA1NCOA3KMT2AMAPT | |
| SCHEMBL1726759 | 0.77 | KDM4E (0.50) | LMNAMAPTL3MBTL1ALDH1A1GAA | |
| SCHEMBL29633582 | 0.77 | KDM4E (0.51) | LMNAKMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL30164563 | 0.77 | KDM4E (0.50) | LMNAMAPTL3MBTL1ALDH1A1GAA | |
| SCHEMBL28030473 | 0.77 | TSHR (0.66) | LMNAKMT2AMEN1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139145-A1 | NOVEL PYRIMIDINE AND PYRIDINE COMPOUNDS AND USAGE THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-09-18 | — | — | WO | disclosed |