Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254318 | 0.82 | ERAP1 (0.51) | ERAP1DAOLTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL2257910 | 0.77 | ALDH1A1 (0.57) | ERAP1DAOLTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL10966990 | 0.75 | LTA4H (0.57) | ERAP1LTA4HALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27884 | 0.70 | LTA4H (0.81) | LTA4HALDH1A1SMN1; SMN2LMNACYP2D6 | |
| SCHEMBL1425001 | 0.70 | LTA4H (0.81) | LTA4HALDH1A1SMN1; SMN2LMNACYP2D6 | |
| SCHEMBL25986524 | 0.70 | LTA4H (0.81) | LTA4HALDH1A1SMN1; SMN2LMNACYP2D6 | |
| SCHEMBL1774447 | 0.69 | LTA4H (0.65) | LTA4HALDH1A1SMN1; SMN2LMNACYP2D6 | |
| SCHEMBL5377402 | 0.69 | ERAP1 (0.55) | ERAP1LTA4HALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17963974 | 0.69 | ERAP1 (0.48) | ERAP1DAOLTA4HALDH1A1SMN1; SMN2 | |
| SCHEMBL9718488 | 0.68 | LTA4H (0.53) | ERAP1LTA4HALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968324-A1 | SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014150114-A1 | SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014139150-A1 | SUBSTITUTED PYRIDIZINONE DERIVATIVES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-18 | — | — | WO | disclosed |