Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29506237 | 0.85 | MAPT (0.46) | MAPTTP53ALDH1A1HPGDALOX15 | |
| SCHEMBL276699 | 0.85 | MAPT (0.46) | MAPTTP53ALDH1A1HPGDALOX15 | |
| SCHEMBL29506236 | 0.85 | MAPT (0.46) | MAPTTP53ALDH1A1HPGDALOX15 | |
| Hydrochloric Acid SCHEMBL22092050 | 0.83 | MAPT (0.44) | MAPTTP53ALDH1A1HPGDALOX15 | |
| SCHEMBL27333832 | 0.83 | MAPT (0.44) | MAPTTP53ALDH1A1HPGDALOX15 | |
| Trifluoroacetic Acid SCHEMBL31197673 | 0.73 | SMN1; SMN2 (0.52) | MAPTTP53ALDH1A1HPGDELANE | |
| Quinoxaline SCHEMBL28035806 | 0.70 | ALDH1A1 (0.45) | MAPTALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL27899495 | 0.70 | MAPT (0.34) | MAPTTP53ALDH1A1HPGDALOX15 | |
| Trifluoroacetic Acid SCHEMBL8362809 | 0.69 | KDM4E (0.45) | MAPTALDH1A1HPGDHSD17B10GAA | |
| Trifluoroacetic Acid SCHEMBL27827825 | 0.68 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970282-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | Incyte Corporation (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014143768-A1 | TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS | INCYTE CORPORATION (US) | 2014-09-18 | — | — | WO | disclosed |