Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 13/20 | 0.86 |
| ▸ | NR1I2 | O75469 | 12/20 | 0.86 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.86 |
| ▸ | RORA | P35398 | 5/20 | 0.86 |
| ▸ | RORB | Q92753 | 5/20 | 0.86 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.86 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.86 |
| ▸ | RXRA | P19793 | 1/20 | 0.86 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.86 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.86 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.86 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.86 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.86 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.86 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.86 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| T091317 SCHEMBL457231 | 0.92 | RORC (1.00) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL13651537 | 0.88 | NR1I2 (1.00) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL6032023 | 0.84 | NR1I2 (0.79) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL3388210 | 0.82 | NR1I2 (0.78) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL14732110 | 0.82 | RORC (1.00) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL12334077 | 0.80 | RORC (0.81) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL14300433 | 0.80 | NR1H2 (0.71) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL16731518 | 0.79 | RORC (0.81) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL14732184 | 0.79 | RORC (0.77) | RORCNR1I2NR1H2RORARORB | |
| SCHEMBL7022970 | 0.77 | NR1H2 (0.71) | RORCNR1I2NR1H2RORARORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160033531-A1 | METHOD AND COMPOSITIONS FOR DETECTING BINDING TO THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL | 2016-02-04 | — | — | US | disclosed |
| WO-2014145202-A1 | METHODS AND COMPOSITIONS FOR DETECTING BINDING TO THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-18 | — | — | WO | disclosed |