Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.81 |
| ▸ | NR1H2 | P55055 | 10/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.74 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.74 |
| ▸ | RORA | P35398 | 3/20 | 0.74 |
| ▸ | RORB | Q92753 | 3/20 | 0.74 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | RXRA | P19793 | 1/20 | 0.74 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.74 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.74 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.74 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.74 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.74 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.74 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.74 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.74 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013542 | 0.89 | RORC (0.76) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL7016049 | 0.86 | RORC (0.76) | RORCNR1H2NR1I2NR1H3RORA | |
| T091317 SCHEMBL457231 | 0.85 | RORC (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14732110 | 0.85 | RORC (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14732184 | 0.84 | RORC (0.77) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL7022970 | 0.82 | NR1H2 (0.71) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL16063605 | 0.79 | RORC (0.86) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL2762946 | 0.78 | NR1H3 (1.00) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL14300433 | 0.78 | NR1H2 (0.71) | RORCNR1H2NR1I2NR1H3RORA | |
| SCHEMBL21115115 | 0.74 | RORC (0.46) | RORCNR1H2NR1I2NR1H3RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586928-B2 | Modulators of the nuclear hormone receptor ROR | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-07 | — | — | US | disclosed |
| US-20160310454-A1 | LIVER X RECEPTOR AGONISTS IN THE TREATMENT OF EMPHYSEMA | D'ARMIENTO JEANINE (US) | 2016-10-27 | — | — | US | disclosed |
| US-20150141390-A1 | PLANT STEROIDS AND USES THEREOF | DAVIDSON LOPEZ, LLC (US) | 2015-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141390-A1 | PLANT STEROIDS AND USES THEREOF | CYP46A1, CYP17A1, NR1H4 | RORC 65/4885NR1H2 27/4885NR1I2 124/4885 |
| US-20160310454-A1 | LIVER X RECEPTOR AGONISTS IN THE TREATMENT OF EMPHYSEMA | TLR3, NR1H2, TLR4 | RORC 180/4885NR1H2 2/4885NR1I2 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.