Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16064609 | 0.87 | CTSC (0.43) | — | |
| SCHEMBL18643728 | 0.86 | PREP (0.42) | PREPHTRA1DPP4XIAPELANE | |
| SCHEMBL16064115 | 0.86 | PREP (0.42) | PREPHTRA1DPP4XIAPELANE | |
| SCHEMBL16064424 | 0.85 | PREP (0.41) | PREPHTRA1DPP4XIAPELANE | |
| SCHEMBL22643283 | 0.85 | PREP (0.41) | PREPHTRA1DPP4XIAPELANE | |
| SCHEMBL16064560 | 0.82 | CTSC (0.46) | PREPDPP4 | |
| SCHEMBL21076252 | 0.81 | PREP (0.38) | PREPHTRA1DPP4XIAP | |
| SCHEMBL21173320 | 0.81 | PREP (0.38) | PREPHTRA1DPP4XIAPELANE | |
| SCHEMBL22642863 | 0.81 | PREP (0.40) | PREPHTRA1DPP4XIAPGPR119 | |
| SCHEMBL20384053 | 0.81 | PREP (0.40) | PREPHTRA1DPP4XIAPGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |
| WO-2014140075-A1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-09-18 | — | — | WO | disclosed |