Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16064424 | 1.00 | PREP (0.41) | PREPDPP4HTRA1GPR119XIAP | |
| SCHEMBL18643728 | 0.89 | PREP (0.42) | PREPDPP4HTRA1GPR119XIAP | |
| SCHEMBL16064115 | 0.89 | PREP (0.42) | PREPDPP4HTRA1GPR119XIAP | |
| SCHEMBL21233252 | 0.88 | PREP (0.41) | PREPDPP4GPR119CHRM2CHRM1 | |
| SCHEMBL21172945 | 0.87 | PREP (0.40) | PREPDPP4GPR119CHRM2CHRM1 | |
| SCHEMBL16075199 | 0.87 | CTSC (0.45) | — | |
| SCHEMBL18373188 | 0.87 | CTSC (0.45) | — | |
| SCHEMBL16064560 | 0.86 | CTSC (0.46) | PREPDPP4 | |
| SCHEMBL16064675 | 0.85 | PREP (0.39) | PREPDPP4HTRA1GPR119XIAP | |
| SCHEMBL22642863 | 0.84 | PREP (0.40) | PREPDPP4HTRA1GPR119XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970283-B1 | SUBSTITUTED 2-AZA-BICYCLO[2.2.1]HEPTANE-3-CARBOXYLIC ACID (BENZYL-CYANO-METHYL)-AMIDES INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2020-11-11 | — | — | EP | disclosed |