Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2374 | 0.98 | SLC6A4 (0.88) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL3517380 | 0.95 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL3521364 | 0.95 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL16205160 | 0.95 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL10008912 | 0.83 | SLC6A4 (0.92) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL872306 | 0.83 | SLC6A4 (0.92) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL17999801 | 0.81 | SLC6A3 (0.66) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL17999818 | 0.81 | SLC6A3 (0.66) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL17999816 | 0.81 | SLC6A3 (0.66) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 | |
| SCHEMBL16298324 | 0.81 | SLC6A4 (0.76) | SLC6A4SLC6A3SLC6A2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | claimed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | claimed |
| WO-2000073379-A1 | PROCESS FOR PREPARING A STABILIZED POLYESTER | SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) | 2000-12-07 | — | — | WO | disclosed |
| US-6127424-A | N-METHYL-1-(1-(4-CHLOROPHENYL)CYCLOBUTYL)-3-METHYLBUTYLAMINE OR A PHARMACEUTICALLY SUITABLE SALT AS AN EXAMPLE; BIOAVAILABILITY; SIDE EFFECT REDUCTION | KNOLL AKTIENGESESLLSCHAFT (DE) | 2000-10-03 | — | — | US | disclosed |
| EP-0828484-A1 | USE OF ARYL SUBSTITUTED CYCLOBUTYL ALKYL AMINES FOR THE TREATMENT OF OBESITY | Knoll AG (DE) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996038134-A1 | USE OF ARYL SUBSTITUTED CYCLOBUTYL ALKYL AMINES FOR THE TREATMENT OF OBESITY | KNOLL AG (DE) | 1996-12-05 | — | — | WO | disclosed |
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |
| US-4629727-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0111994-B1 | (1-ARYLCYCLOBUTYL) ALKYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | disclosed |
| EP-0111994-A1 | (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents | The Boots Company PLC (GB) | 1984-06-27 | — | — | EP | disclosed |