Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10003483 | 0.92 | SMO (0.57) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL16588414 | 0.90 | SMO (0.50) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL10003621 | 0.84 | SMO (0.54) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL10003290 | 0.81 | P2RX3 (0.35) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL10003592 | 0.80 | SMO (0.59) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL10003179 | 0.80 | SMO (0.44) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL10003375 | 0.80 | SMO (0.55) | SMOEPHX2HSD17B10 | |
| SCHEMBL10004367 | 0.80 | SMO (0.62) | SMOMEN1KMT2APOLBNPSR1 | |
| SCHEMBL12824880 | 0.79 | SMO (0.41) | SMOMEN1KMT2AEPHX2MAPT | |
| SCHEMBL10004349 | 0.79 | HTT (0.44) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471789-B1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2014-09-17 | — | — | EP | disclosed |