Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 3/20 | 0.31 |
| ▸ | GABRD | O14764 | 3/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.31 |
| ▸ | GABRE | P78334 | 3/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31106358 | 0.80 | GABRG2 (0.44) | NPC1RAB9ANOS1GABRPGABRD | |
| SCHEMBL23360135 | 0.80 | GABRG2 (0.44) | NPC1RAB9ANOS1GABRPGABRD | |
| SCHEMBL161864 | 0.75 | CYP1A2 (0.45) | NPC1RAB9AKDM4EDRD3KCNH2 | |
| SCHEMBL12930800 | 0.74 | GABRP (0.40) | KMT2ANOS1AXLGABRPGABRD | |
| SCHEMBL28666568 | 0.73 | FGFR1 (0.39) | KMT2ASMN1; SMN2LMNANOS1AXL | |
| SCHEMBL30184761 | 0.73 | FGFR1 (0.39) | KMT2ASMN1; SMN2LMNANOS1AXL | |
| SCHEMBL2747957 | 0.70 | KDM4E (0.36) | KMT2ASMN1; SMN2NOS1AXLBACE1 | |
| SCHEMBL31399686 | 0.70 | CYP1A2 (0.53) | SMN1; SMN2LMNANOS1AXLBACE1 | |
| SCHEMBL2171256 | 0.70 | CYP1A2 (0.53) | SMN1; SMN2LMNANOS1AXLBACE1 | |
| SCHEMBL31106357 | 0.70 | KDM4E (0.36) | KMT2ASMN1; SMN2NOS1AXLBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2663553-A2 | QUINOLINE AND ISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012030944-A2 | QUINOLINE AND ISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
| EP-2346830-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck Sharp & Dohme Corp. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010030722-A1 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2010-03-18 | — | — | WO | disclosed |