Sugi Predict

Sugi Predict / Compounds / SCHEMBL1607230

SCHEMBL1607230

SCHEMBL1607230

Cc1ccc2c(B(O)O)cn(C(=O)OC(C)(C)C)c2c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.44
▸ HTR6 P50406 1/20 0.40
▸ GPR119 Q8TDV5 2/20 0.37
▸ LMNA P02545 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ KMT2A Q03164 2/20 0.34
▸ BCHE P06276 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ ACHE P22303 1/20 0.34
▸ EPHX2 P34913 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ PIM1 P11309 1/20 0.33
▸ MARK3 P27448 1/20 0.33
▸ MAP4K2 Q12851 1/20 0.33
▸ CAMK2B Q13554 1/20 0.33
▸ PIM3 Q86V86 1/20 0.33
▸ PIM2 Q9P1W9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1606364 0.85 L3MBTL1 (0.41) L3MBTL1HTR6LMNAKMT2ACYP3A4
SCHEMBL19473273 0.84 MEN1 (0.42) L3MBTL1HTR6GPR119LMNANPSR1
SCHEMBL23330894 0.82 L3MBTL1 (0.43) L3MBTL1HTR6GPR119LMNANPSR1
SCHEMBL22749426 0.82 L3MBTL1 (0.45) L3MBTL1HTR6GPR119LMNANPSR1
SCHEMBL29333138 0.82 L3MBTL1 (0.43) L3MBTL1HTR6GPR119LMNANPSR1
SCHEMBL15564936 0.82 GPR119 (0.42) L3MBTL1HTR6GPR119
SCHEMBL966206 0.82 L3MBTL1 (0.60) L3MBTL1HTR6KMT2ABCHEACHE
SCHEMBL29377863 0.82 L3MBTL1 (0.60) L3MBTL1HTR6KMT2ABCHEACHE
Ammonia Solution, Strong SCHEMBL15566336 0.81 GPR119 (0.41) L3MBTL1HTR6GPR119
SCHEMBL22919485 0.80 L3MBTL1 (0.55) L3MBTL1HTR6GPR119LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307371-B1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2017-10-04 — — EP disclosed
US-9242963-B2 Organic compounds NOVARTIS AG (CH) 2016-01-26 — — US disclosed
US-20150210672-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2015-07-30 — — US disclosed
US-20140288126-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2014-09-25 — — US disclosed
US-8791141-B2 Organic compounds NOVARTIS AG (CH) 2014-07-29 — — US disclosed
US-8030334-B2 Organic compounds NOVARTIS AG (CH) 2011-10-04 — — US disclosed
US-20110082129-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2011-04-07 — — US disclosed
US-20100261698-A1 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2010-10-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110082129-A1 ORGANIC COMPOUNDS SLCO2B1, SLCO1B1, SLCO1B3 L3MBTL1 4840/4885HTR6 1410/4885GPR119 2655/4885
US-20100261698-A1 ORGANIC COMPOUNDS SLCO2B1, SLCO1B1, SLCO1B3 L3MBTL1 4840/4885HTR6 1410/4885GPR119 2655/4885
US-20150210672-A1 ORGANIC COMPOUNDS SLCO2B1, SLCO1B1, SLCO1B3 L3MBTL1 4727/4885HTR6 1454/4885GPR119 2810/4885
US-20140288126-A1 ORGANIC COMPOUNDS SLCO2B1, SLCO1B1, SLCO1B3 L3MBTL1 4727/4885HTR6 1454/4885GPR119 2810/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.