Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1607018 | 0.94 | NOS3 (0.39) | NOS3NOS2TSHREPHX2MEN1 | |
| SCHEMBL497630 | 0.74 | TSHR (0.38) | NOS3NOS2TSHREPHX2MEN1 | |
| SCHEMBL1606341 | 0.72 | TSHR (0.40) | NOS3NOS2TSHREPHX2MEN1 | |
| SCHEMBL1607650 | 0.71 | NOS3 (0.36) | NOS3NOS2 | |
| SCHEMBL845066 | 0.71 | CHRM2 (0.38) | NOS3NOS2 | |
| SCHEMBL577126 | 0.70 | — | — | |
| SCHEMBL498175 | 0.69 | — | — | |
| SCHEMBL2263409 | 0.68 | KDM4E (0.36) | KDM4E | |
| SCHEMBL1607683 | 0.67 | NOS3 (0.40) | NOS3NOS2TSHRKDM4EALDH1A1 | |
| SCHEMBL7165129 | 0.67 | ALDH1A1 (0.38) | NOS3NOS2TSHREPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518975-B2 | Gamma secretase modulators | Merck Sharp + Dohme Corp. (US) | 2013-08-27 | — | — | US | disclosed |
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION | 2011-04-07 | — | — | US | disclosed |
| EP-2200990-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009032277-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |
| US-4774236-A | ANTICARCINOGENS, PROGESTATIONAL AND ANTIPROGESTATIONAL ACTIVITY | RESEARCH TRIANGLE INSTITUTE (US) | 1988-09-27 | — | — | US | disclosed |
| WO-1988001868-A1 | 17alpha-(SUBSTITUTED-METHYL)-17beta-HYDROXY/ESTERIFIED HYDROXY STEROIDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RESEARCH TRIANGLE INSTITUTE (US) | 1988-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082153-A1 | GAMMA SECRETASE MODULATORS | BACE1, BACE2, PSEN1 | NOS3 4452/4885NOS2 4563/4885TSHR 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.