Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TTPA | P49638 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16077006 | 0.88 | GSTO1 (0.56) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10295720 | 0.85 | PSEN1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL12919621 | 0.84 | PSEN1 (0.84) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL12989326 | 0.83 | MEN1 (0.53) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16077004 | 0.82 | PSEN1 (0.50) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL13139050 | 0.81 | PSEN1 (0.51) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16077014 | 0.81 | GSTO1 (0.49) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL16260622 | 0.81 | LMNA (0.67) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL1258674 | 0.81 | LMNA (0.67) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL28390427 | 0.81 | LMNA (0.67) | PSEN1MEN1KMT2APDE4APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133225-B2 | Dual targeting anticancer agents | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140274988-A1 | DUAL TARGETING ANTICANCER AGENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140274988-A1 | DUAL TARGETING ANTICANCER AGENTS | CCNE1, CCNE2, VHL | PSEN1 1185/4885MEN1 1984/4885KMT2A 2016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.