Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 5/20 | 0.78 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.78 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.78 |
| ▸ | P2RY1 | P47900 | 7/20 | 0.75 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.75 |
| ▸ | SRC | P12931 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.75 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.72 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.71 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.71 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.71 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.71 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.67 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.67 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.67 |
| ▸ | LDHA | P00338 | 1/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
| ▸ | FBP1 | P09467 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine Triphosphate SCHEMBL27962123 | 0.90 | P2RY1 (0.93) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL19834218 | 0.90 | P2RY1 (0.93) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL7133726 | 0.90 | P2RY1 (0.93) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL3498798 | 0.89 | P2RY1 (0.91) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL27783351 | 0.89 | P2RY1 (0.91) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL4594616 | 0.89 | P2RY1 (0.91) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL4362224 | 0.89 | P2RY1 (0.94) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Diphosphate SCHEMBL11581047 | 0.89 | P2RY1 (0.91) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| SCHEMBL4997435 | 0.89 | P2RY1 (0.94) | P2RX1P2RX3P2RX2P2RY1P2RY2 | |
| Adenosine Triphosphate SCHEMBL18089781 | 0.89 | P2RY1 (0.94) | P2RX1P2RX3P2RX2P2RY1P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10231986-B2 | Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV | IDENIX PHARMACEUTICALS LLC (US) | 2019-03-19 | — | — | US | disclosed |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | UNIVERSITE DE MONTPELLIER (FR) | 2016-04-28 | — | — | US | disclosed |
| WO-2014160484-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | IDENIX PHARMACEUTICALS, INC. | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10231986-B2 | Amino acid phosphoramidate pronucleotides of 2′-cyano, azido and amino nucleosides for the treatment of HCV | PNP, RNGTT, NSUN2 | P2RX1 85/4885P2RX3 145/4885P2RX2 190/4885 |
| US-20160113956-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | P2RX1 84/4885P2RX3 144/4885P2RX2 185/4885 |
| US-20140271547-A1 | AMINO ACID PHOSPHORAMIDATE PRONUCLEOTIDES OF 2'-CYANO, AZIDO AND AMINO NUCLEOSIDES FOR THE TREATMENT OF HCV | PNP, RNGTT, NSUN2 | P2RX1 84/4885P2RX3 144/4885P2RX2 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.