Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 10/20 | 0.85 |
| ▸ | ATM | Q13315 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17480781 | 0.90 | ATM (0.71) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082519 | 0.87 | TP53 (0.65) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082509 | 0.86 | TP53 (0.75) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082518 | 0.83 | TP53 (1.00) | TP53LMNAKMT2AMEN1MAPT | |
| SCHEMBL17480774 | 0.77 | TP53 (0.61) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL25411 | 0.77 | HSD17B10 (0.80) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082498 | 0.77 | TP53 (0.85) | TP53LMNAKMT2AMEN1HPGD | |
| SCHEMBL31451 | 0.76 | ATM (0.67) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082522 | 0.74 | TP53 (0.82) | TP53LMNAKMT2AMEN1MAPT | |
| SCHEMBL13666372 | 0.74 | TP53 (0.60) | TP53LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790188-B2 | Benzimidazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-10-17 | — | — | US | disclosed |
| WO-2014145887-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-09-18 | — | — | WO | disclosed |