Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 7/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17480774 | 0.91 | TP53 (0.61) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082491 | 0.87 | TP53 (0.85) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082518 | 0.78 | TP53 (1.00) | TP53LMNAKMT2AMEN1TDP1 | |
| SCHEMBL17480781 | 0.77 | ATM (0.71) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL16082509 | 0.75 | TP53 (0.75) | TP53ATMLMNAKMT2AMEN1 | |
| SCHEMBL7671757 | 0.73 | TP53 (0.59) | TP53TDP1 | |
| SCHEMBL16082498 | 0.72 | TP53 (0.85) | TP53LMNAKMT2AMEN1TDP1 | |
| SCHEMBL6170907 | 0.71 | AGTR1 (0.66) | LMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6168674 | 0.71 | AGTR1 (0.57) | LMNATDP1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6169384 | 0.71 | PDE2A (0.53) | TP53LMNATDP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790188-B2 | Benzimidazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-10-17 | — | — | US | disclosed |
| WO-2014145887-A1 | BENZIMIDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-09-18 | — | — | WO | disclosed |