Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1607627 | 0.88 | HDAC6 (0.51) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1608508 | 0.87 | HDAC6 (0.52) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1607602 | 0.87 | HDAC6 (0.50) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1607617 | 0.86 | HDAC6 (0.61) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1608716 | 0.86 | HDAC6 (0.44) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL25281869 | 0.85 | HDAC6 (0.43) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1609082 | 0.85 | RXFP1 (0.42) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL1608477 | 0.85 | HDAC6 (0.42) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL24071549 | 0.85 | TP53 (0.44) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL24071323 | 0.84 | TP53 (0.43) | HDAC6HDAC8HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12606557-B2 | Substituted indoles with inhibitory activity | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2026-04-21 | — | — | US | disclosed |
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER HIGHER EDUCATION (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER HIGHER EDUCATION (US) | 2023-06-22 | — | — | US | disclosed |
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER HIGHER EDUCATION (US) | 2023-06-22 | — | — | US | disclosed |
| WO-2021243018-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2021-12-02 | — | — | WO | disclosed |
| US-20150320758-A1 | SELECTIVE INHIBITORS OF HISTONE DEACTYLASE | PHARMACYCLICS LLC | 2015-11-12 | — | — | US | disclosed |
| US-8906954-B2 | Selective inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140004174-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8466193-B2 | Selective inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2013-06-18 | — | — | US | disclosed |
| US-20110081409-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS LLC | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110081409-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC11 | HDAC6 11/4885HDAC8 1/4885HDAC1 2/4885 |
| US-12606557-B2 | Substituted indoles with inhibitory activity | IDO1, BCL9, IDO2 | HDAC6 1994/4885HDAC8 1050/4885HDAC1 686/4885 |
| US-20230192684-A1 | SUBSTITUTED INDOLES WITH INHIBITORY ACTIVITY | IDO1, IDO2, INMT | HDAC6 1523/4885HDAC8 2097/4885HDAC1 1028/4885 |
| US-20150320758-A1 | SELECTIVE INHIBITORS OF HISTONE DEACTYLASE | HDAC8, HDAC1, HDAC5 | HDAC6 11/4885HDAC8 1/4885HDAC1 2/4885 |
| US-20140004174-A1 | SELECTIVE INHIBITORS OF HISTONE DEACETYLASE | HDAC8, HDAC1, HDAC11 | HDAC6 11/4885HDAC8 1/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.