Sugi Predict

Sugi Predict / Compounds / SCHEMBL1608477

SCHEMBL1608477

SCHEMBL1608477

CS(=O)(=O)c1ccc(Cn2ccc3ccc(C(=O)NO)nc32)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HDAC6 Q9UBN7 11/20 0.42
▸ HDAC1 Q13547 8/20 0.42
▸ HDAC4 P56524 2/20 0.42
▸ HDAC8 Q9BY41 9/20 0.42
▸ HDAC2 Q92769 7/20 0.42
▸ HDAC10 Q969S8 4/20 0.42
▸ HDAC9 Q9UKV0 2/20 0.42
▸ HDAC3 O15379 6/20 0.42
▸ HDAC11 Q96DB2 2/20 0.42
▸ HDAC7 Q8WUI4 1/20 0.42
▸ HDAC5 Q9UQL6 1/20 0.42
▸ NCOR2 Q9Y618 1/20 0.42
▸ PTGDR2 Q9Y5Y4 3/20 0.38
▸ MAPK8 P45983 2/20 0.38
▸ MAPK9 P45984 1/20 0.38
▸ MAPK10 P53779 1/20 0.38
▸ HSD17B13 Q7Z5P4 1/20 0.37
▸ PDE4A P27815 1/20 0.37
▸ PDE4B Q07343 1/20 0.37
▸ PDE4C Q08493 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1608085 0.87 ADRA1D (0.41) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1608418 0.85 HDAC6 (0.52) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1607627 0.84 HDAC6 (0.51) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1608508 0.83 HDAC6 (0.52) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1607602 0.83 HDAC6 (0.50) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1607617 0.82 HDAC6 (0.61) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1608716 0.82 HDAC6 (0.44) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL1608599 0.81 HDAC3 (0.38) HDAC6HDAC1HDAC8HDAC2HDAC3
SCHEMBL25281869 0.81 HDAC6 (0.43) HDAC6HDAC1HDAC4HDAC8HDAC2
SCHEMBL24071249 0.80 KCNQ3 (0.46) HDAC6HDAC1HDAC4HDAC8HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150320758-A1 SELECTIVE INHIBITORS OF HISTONE DEACTYLASE PHARMACYCLICS LLC 2015-11-12 — — US disclosed
US-8906954-B2 Selective inhibitors of histone deacetylase PHARMACYCLICS, INC. (US) 2014-12-09 — — US disclosed
US-20140004174-A1 SELECTIVE INHIBITORS OF HISTONE DEACETYLASE PHARMACYCLICS, INC. (US) 2014-01-02 — — US disclosed
US-8466193-B2 Selective inhibitors of histone deacetylase PHARMACYCLICS, INC. (US) 2013-06-18 — — US disclosed
US-20110081409-A1 SELECTIVE INHIBITORS OF HISTONE DEACETYLASE PHARMACYCLICS LLC 2011-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110081409-A1 SELECTIVE INHIBITORS OF HISTONE DEACETYLASE HDAC8, HDAC1, HDAC11 HDAC6 11/4885HDAC1 2/4885HDAC4 8/4885
US-20150320758-A1 SELECTIVE INHIBITORS OF HISTONE DEACTYLASE HDAC8, HDAC1, HDAC5 HDAC6 11/4885HDAC1 2/4885HDAC4 10/4885
US-20140004174-A1 SELECTIVE INHIBITORS OF HISTONE DEACETYLASE HDAC8, HDAC1, HDAC11 HDAC6 11/4885HDAC1 2/4885HDAC4 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.