Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 5/20 | 0.60 |
| ▸ | VNN1 | O95497 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CYP46A1 | Q9Y6A2 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16049701 | 0.85 | AVPR1A (0.58) | PKLRALDH1A1LMNACHRM2CYP46A1 | |
| SCHEMBL21977074 | 0.81 | PKLR (0.54) | PKLRALDH1A1LMNACYP46A1CYP3A4 | |
| SCHEMBL21976690 | 0.78 | PKLR (0.61) | PKLRCYP46A1CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL22422383 | 0.77 | PKM (0.62) | ALDH1A1LMNA | |
| SCHEMBL21976475 | 0.76 | PKLR (0.67) | PKLRALDH1A1LMNANAMPTCHRM2 | |
| SCHEMBL21976622 | 0.75 | PKLR (0.70) | PKLR | |
| SCHEMBL16084021 | 0.75 | PKLR (1.00) | PKLR | |
| SCHEMBL21975989 | 0.75 | PKLR (0.66) | PKLRALDH1A1LMNACYP46A1CYP3A4 | |
| SCHEMBL16083890 | 0.75 | PKLR (0.69) | PKLR | |
| SCHEMBL16049785 | 0.75 | PKLR (1.00) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014139325-A1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2014-09-18 | — | — | WO | disclosed |