Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SCD | O00767 | 13/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16085425 | 0.89 | SCD (0.61) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085525 | 0.85 | LMNA (0.53) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085539 | 0.85 | LMNA (0.57) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085613 | 0.84 | SCD (0.55) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085610 | 0.82 | SCD (0.65) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085429 | 0.82 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085488 | 0.81 | MEN1 (0.61) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085404 | 0.81 | KMT2A (0.74) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085570 | 0.81 | ABL1 (0.59) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL16085487 | 0.80 | ABL1 (0.60) | LMNAMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145642-A9 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014145642-A2 | NRF2 SMALL MOLECULE INHIBITORS FOR CANCER THERAPY | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |
| US-8728631-B2 | Dendrimer compound and organic luminescent device employing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-05-20 | — | — | US | disclosed |