Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4110544 | 0.90 | MCHR1 (0.40) | MCHR1IRAK4HPGDPDE4BPDE4A | |
| SCHEMBL4110540 | 0.90 | MCHR1 (0.40) | MCHR1IRAK4HPGDPDE4BPDE4A | |
| SCHEMBL4107432 | 0.83 | HPGD (0.40) | MCHR1IRAK4HPGDPDE4BPDE4A | |
| SCHEMBL4107426 | 0.83 | HPGD (0.40) | MCHR1IRAK4HPGDPDE4BPDE4A | |
| SCHEMBL8177115 | 0.83 | IRAK4 (0.41) | IRAK4PDE4BPDE4APDE4DMERTK | |
| SCHEMBL4100544 | 0.81 | HCAR3 (0.38) | IRAK4JAK2 | |
| SCHEMBL13697674 | 0.78 | IRAK4 (0.40) | IRAK4HPGDPDE4BPDE4APDE4D | |
| SCHEMBL8176391 | 0.76 | SELP (0.39) | MCHR1HPGDPDE4BTYRO3JAK2 | |
| SCHEMBL4105480 | 0.76 | HPGD (0.36) | MCHR1IRAK4HPGDPDE4BPDE4A | |
| SCHEMBL4105477 | 0.76 | HPGD (0.36) | MCHR1IRAK4HPGDPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084236-A1 | CHEMICAL COMPOUNDS 635 : PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |