Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 17/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 16/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23472180 | 0.81 | ALDH1A1 (0.43) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17209862 | 0.78 | KDM4E (0.41) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21346508 | 0.78 | KDM4E (0.41) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL26894623 | 0.78 | KDM4E (0.41) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18649619 | 0.77 | CYP1A2 (0.40) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL30977957 | 0.76 | LRRK2 (0.41) | CYP3A4CYP1A2CYP2D6CYP2C19TSHR | |
| SCHEMBL21365185 | 0.76 | STK17A (0.47) | CYP3A4CYP1A2TSHRALOX15HSD17B10 | |
| SCHEMBL13225322 | 0.76 | — | — | |
| SCHEMBL29607566 | 0.75 | CRHR1 (0.39) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL24869158 | 0.75 | KDM4E (0.39) | KDM4ECYP3A4CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044641-A2 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |
| WO-2014144169-A1 | CARM1 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |