Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 5/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886458 | 0.82 | CHRNA7 (0.50) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL11905640 | 0.81 | L3MBTL1 (0.44) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL11905224 | 0.81 | L3MBTL1 (0.44) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL11905220 | 0.81 | L3MBTL1 (0.44) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL11905218 | 0.81 | L3MBTL1 (0.44) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL17044018 | 0.77 | L3MBTL1 (0.45) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL6888079 | 0.77 | L3MBTL1 (0.45) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL1672235 | 0.77 | CHRNA7 (0.45) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL16103946 | 0.74 | L3MBTL1 (0.47) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 | |
| SCHEMBL11922980 | 0.74 | L3MBTL1 (0.47) | L3MBTL1IP6K1KDM4EACVR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841289-B2 | Heterocyclic derivatives | MERCK SHARP & DOHME B.V. (US) | 2014-09-23 | — | — | US | disclosed |