Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6886458 | 0.93 | CHRNA7 (0.50) | CHRNA7L3MBTL1ACVR1IP6K1KDM4E | |
| SCHEMBL11905640 | 0.88 | L3MBTL1 (0.44) | CHRNA7L3MBTL1ACVR1IP6K1KDM4E | |
| SCHEMBL11905218 | 0.88 | L3MBTL1 (0.44) | CHRNA7L3MBTL1ACVR1IP6K1KDM4E | |
| SCHEMBL11905220 | 0.88 | L3MBTL1 (0.44) | CHRNA7L3MBTL1ACVR1IP6K1KDM4E | |
| SCHEMBL11905224 | 0.88 | L3MBTL1 (0.44) | CHRNA7L3MBTL1ACVR1IP6K1KDM4E | |
| SCHEMBL6887381 | 0.84 | CHRNA7 (0.50) | CHRNA7L3MBTL1ACVR1SYKKCNH2 | |
| SCHEMBL6886724 | 0.82 | ACVR1 (0.49) | CHRNA7ACVR1KDM4EKCNH2CHRNA1 | |
| SCHEMBL1669065 | 0.80 | IP6K1 (0.60) | CHRNA7IP6K1 | |
| SCHEMBL6887828 | 0.77 | CHRNA7 (0.43) | CHRNA7ALDH1A1 | |
| SCHEMBL1670209 | 0.77 | ADRA1A (0.42) | CHRNA7KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488520-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | MSD Oss B.V. (NL) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045258-A1 | CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR | N.V. ORGANON (NL) | 2011-04-21 | — | — | WO | disclosed |