Sugi Predict

Sugi Predict / Compounds / SCHEMBL16093891

SCHEMBL16093891

SCHEMBL16093891

CC(C)(CI)COCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 1/20 0.52
▸ KDM4E B2RXH2 1/20 0.49
▸ POLB P06746 1/20 0.49
▸ TACR1 P25103 2/20 0.41
▸ CA1 P00915 3/20 0.40
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ PRMT1 Q99873 1/20 0.39
▸ IDO1 P14902 1/20 0.39
▸ AGXT P21549 1/20 0.38
▸ ALDH1A1 P00352 2/20 0.37
▸ HMGCR P04035 1/20 0.37
▸ CA2 P00918 2/20 0.37
▸ CA7 P43166 2/20 0.37
▸ CA9 Q16790 2/20 0.37
▸ HPGD P15428 1/20 0.37
▸ ALOX15 P16050 1/20 0.37
▸ ALOX12 P18054 1/20 0.37
▸ CASP1 P29466 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19621150 0.82 TSHR (0.54) TSHRKDM4EPOLBTACR1CA1
SCHEMBL21540753 0.81 TSHR (0.52) TSHRKDM4EPOLBTACR1CA1
SCHEMBL22764730 0.81 TSHR (0.52) TSHRKDM4EPOLBTACR1CA1
SCHEMBL3957626 0.81 KDM4E (0.62) TSHRKDM4EPOLBTACR1CA1
SCHEMBL22701908 0.80 KDM4E (0.49) TSHRKDM4EPOLBTACR1CA1
SCHEMBL1691827 0.79 TSHR (0.61) TSHRKDM4EPOLBTACR1CA1
SCHEMBL20280191 0.79 TSHR (0.50) TSHRKDM4EPOLBTACR1CA1
SCHEMBL18666831 0.78 KDM4E (0.59) TSHRKDM4EPOLBTACR1CA1
SCHEMBL14304175 0.78 KDM4E (0.54) TSHRKDM4EPOLBTACR1CA1
SCHEMBL6043011 0.78 TSHR (0.58) TSHRKDM4EPOLBTACR1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240182426-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. 2024-06-06 — — US disclosed
US-11725008-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-08-15 — — US disclosed
US-11725008-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-08-15 — — US disclosed
US-11725008-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-08-15 — — US disclosed
US-20230027126-A1 ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-01-26 — — US disclosed
US-20230027126-A1 ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2023-01-26 — — US disclosed
US-11512053-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2022-11-29 — — US disclosed
CN-109265400-B Arginine methyltransferase inhibitors and uses thereof EPIZYME股份有限公司 2022-10-04 — — CN disclosed
US-11028083-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-06-08 — — US disclosed
US-11028083-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-06-08 — — US disclosed
US-20170267642-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2017-09-21 — — US disclosed
US-9598374-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2017-03-21 — — US disclosed
US-9598374-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2017-03-21 — — US disclosed
US-9598374-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2017-03-21 — — US disclosed
WO-2016044626-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2016-03-24 — — WO disclosed
US-20160024016-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2016-01-28 — — US disclosed
US-20160024016-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2016-01-28 — — US disclosed
EP-2970132-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2016-01-20 — — EP disclosed
WO-2014153226-A9 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2015-01-08 — — WO disclosed
WO-2014153226-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-09-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11512053-B2 Arginine methyltransferase inhibitors and uses thereof PRMT1, PRMT3, PRMT5 TSHR 3035/4885KDM4E 157/4885POLB 2003/4885
US-20170267642-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 TSHR 3035/4885KDM4E 157/4885POLB 2003/4885
US-20240182426-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 TSHR 3035/4885KDM4E 157/4885POLB 2003/4885
US-11725008-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases PRMT1, PRMT5, PRMT3 TSHR 3473/4885KDM4E 78/4885POLB 2548/4885
US-11028083-B2 Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases PRMT1, PRMT5, PRMT3 TSHR 3473/4885KDM4E 78/4885POLB 2548/4885
US-20160024016-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF PRMT1, PRMT3, PRMT5 TSHR 3035/4885KDM4E 157/4885POLB 2003/4885
US-20230027126-A1 ETHANEDIAMINE-HETEROCYCLE DERIVATIVES AS INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES PRMT1, PRMT5, PRMT3 TSHR 3473/4885KDM4E 78/4885POLB 2548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.