Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 9/20 | 0.69 |
| ▸ | KDM2B | Q8NHM5 | 5/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094531 | 0.92 | KDM4C (0.68) | KDM4CKDM2BTP53POLBMAPK14 | |
| SCHEMBL16033723 | 0.81 | KDM4C (1.00) | KDM4CKDM2BTP53POLBMAPK14 | |
| SCHEMBL16094861 | 0.76 | KDM4C (0.62) | KDM4CKDM2BMAPK14GSK3AGSK3B | |
| SCHEMBL16033542 | 0.75 | KDM4C (1.00) | KDM4CKDM2BNPC1CASP3RAB9A | |
| SCHEMBL16033760 | 0.73 | KDM4C (1.00) | KDM4CKDM2BTP53POLBMAPK14 | |
| SCHEMBL16095914 | 0.71 | MAPK14 (0.50) | KDM4CTP53MAPK14GSK3AGSK3B | |
| SCHEMBL16094879 | 0.70 | KDM4C (0.61) | KDM4CMAPK14GSK3AGSK3B | |
| SCHEMBL16094728 | 0.70 | KDM4C (0.64) | KDM4CKDM2BMAPK14GSK3B | |
| SCHEMBL16033764 | 0.66 | KDM4C (1.00) | KDM4CKDM2BNPC1CASP3RAB9A | |
| SCHEMBL16095105 | 0.64 | MAPK14 (0.46) | KDM4CMAPK14GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |