Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16095105 | 0.92 | MAPK14 (0.46) | MAPK14GSK3BGSK3AKDM4CMAPK13 | |
| SCHEMBL16095177 | 0.84 | KDM4C (0.39) | MAPK14GSK3BKDM4CMAPK13MAPK12 | |
| SCHEMBL16095603 | 0.82 | LMNA (0.38) | MAPK14KDM4CTGFBR1MAPT | |
| SCHEMBL16095224 | 0.80 | MAPK14 (0.48) | MAPK14GSK3BGSK3AMAPK13MAPK12 | |
| SCHEMBL16094861 | 0.80 | KDM4C (0.62) | MAPK14GSK3BGSK3AKDM4C | |
| SCHEMBL16094741 | 0.78 | MAPK14 (0.48) | MAPK14GSK3BGSK3AMAPK13MAPK12 | |
| SCHEMBL17604614 | 0.76 | MAPK14 (0.46) | MAPK14GSK3BMAPK13MAPK12MAPK11 | |
| SCHEMBL16095836 | 0.75 | PHF8 (0.39) | MAPK14KDM4CMAPT | |
| SCHEMBL16094879 | 0.74 | KDM4C (0.61) | MAPK14GSK3BGSK3AKDM4CMAPK13 | |
| SCHEMBL16095079 | 0.74 | ADORA2A (0.39) | KDM4CNPY5RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2969007-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151945-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |