Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887515 | 0.86 | GRIN2D (0.43) | SMN1; SMN2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21594396 | 0.83 | TAAR1 (0.53) | TAAR1IDO1AGXTMAOBSMN1; SMN2 | |
| SCHEMBL13559263 | 0.80 | TAAR1 (0.50) | TAAR1IDO1AGXTMAOBSMN1; SMN2 | |
| SCHEMBL29940749 | 0.79 | IDO1 (0.35) | IDO1 | |
| SCHEMBL1973763 | 0.79 | TAAR1 (0.56) | TAAR1IDO1AGXTMAOBSMN1; SMN2 | |
| SCHEMBL13855831 | 0.78 | HTR3E (0.52) | TAAR1IDO1AGXT | |
| SCHEMBL14648573 | 0.77 | TAAR1 (0.46) | TAAR1IDO1MAOBCYP11B1CYP11B2 | |
| SCHEMBL13921682 | 0.77 | MAOB (0.47) | MAOBTDP1CYP11B1CYP11B2 | |
| SCHEMBL13855839 | 0.77 | MIF (0.53) | TAAR1IDO1AGXTSMN1; SMN2 | |
| SCHEMBL18795026 | 0.77 | CYP1A2 (0.53) | IDO1SMN1; SMN2CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116751171-A | Urea compound and exosome loading method and application thereof | 河南科技大学 | 2023-09-15 | — | — | CN | claimed |
| CN-115636817-A | Isatin derivative containing triazole ring and preparation method and application thereof | 山东大学 | 2023-01-24 | — | — | CN | claimed |
| CN-109705095-B | Fused ring p-benzoquinone CDC25 protein phosphatase inhibitor containing triazole ring, and preparation method and application thereof | 山东大学 | 2021-06-08 | — | — | CN | claimed |
| CN-119101052-A | Matrine-triazole derivative and synthesis method thereof | 吉林医药学院 | 2024-12-10 | — | — | CN | disclosed |
| CN-118440025-B | Zhu Gongjun acid derivative and preparation method and application thereof | 济南爱思医药科技有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-118440025-A | Zhu Gongjun acid derivative and preparation method and application thereof | 济南爱思医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-115636817-B | Isatin derivative containing triazole ring, and preparation method and application thereof | 山东大学 | 2023-11-24 | — | — | CN | disclosed |
| CN-116751171-A | Urea compound and exosome loading method and application thereof | 河南科技大学 | 2023-09-15 | — | — | CN | disclosed |
| CN-115636817-A | Isatin derivative containing triazole ring and preparation method and application thereof | 山东大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-112275322-B | Preparation method and application of supported CNTs @ NHC-Cu catalytic material | 中国科学院兰州化学物理研究所 | 2022-01-25 | — | — | CN | disclosed |
| CN-109096212-B | Method for synthesizing 5-I-1,2, 3-triazole compound by water phase one-pot method | 河南师范大学 | 2021-07-13 | — | — | CN | disclosed |
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-09-29 | — | — | US | disclosed |
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-09-29 | — | — | US | disclosed |
| EP-2976340-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-01-27 | — | — | EP | disclosed |
| CN-105189508-A | Cycloalkyl nitrile pyrazolo pyridones as JANUS kinase inhibitors | MERCK SHARP & DOHME | 2015-12-23 | — | — | CN | disclosed |
| WO-2014146246-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014146490-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014146246-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-09-25 | — | — | WO | disclosed |
| CN-101289460-B | Organoboronic acid compounds and applications thereof as fluorescent probe | UNIV SHANDONG | 2011-09-14 | — | — | CN | disclosed |
| CN-101289460-A | Organoboronic acid compounds and applications thereof as fluorescent probe | UNIV SHANDONG (CN) | 2008-10-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280704-A1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | JAK1, JAK3, JAK2 | TAAR1 1149/4885IDO1 510/4885AGXT 4546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.