Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL162765 | 0.99 | DGAT1 (0.59) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL163112 | 0.90 | DGAT1 (0.58) | DGAT1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL164216 | 0.90 | DGAT1 (0.57) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL164677 | 0.88 | DGAT1 (0.73) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL160909 | 0.88 | DGAT1 (0.57) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL158343 | 0.85 | DGAT1 (0.56) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL161308 | 0.85 | DGAT1 (0.61) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL164678 | 0.85 | DGAT1 (0.56) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL162343 | 0.85 | DGAT1 (0.56) | DGAT1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL161999 | 0.85 | DGAT1 (0.58) | DGAT1HTTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |