Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL164216 | 0.99 | DGAT1 (0.57) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL160987 | 0.90 | DGAT1 (0.59) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL173959 | 0.90 | DGAT1 (0.60) | DGAT1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL162765 | 0.90 | DGAT1 (0.59) | DGAT1CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL160909 | 0.87 | DGAT1 (0.57) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL165743 | 0.87 | DGAT1 (0.73) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL162997 | 0.85 | DGAT1 (0.55) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL160661 | 0.85 | DGAT1 (0.59) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL162202 | 0.85 | DGAT1 (0.57) | DGAT1CA12CA1CA2CA9 | |
| SCHEMBL15022085 | 0.85 | DGAT1 (0.55) | DGAT1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |