Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2913571 | 0.85 | CHRNB4 (0.54) | CHRNB4CHRNA3PDPK1NOS3NOS1 | |
| SCHEMBL30166929 | 0.85 | CHRNB4 (0.59) | CHRNB4CHRNA3PDPK1IDO1CHRNB2 | |
| SCHEMBL221689 | 0.85 | CHRNB4 (0.59) | CHRNB4CHRNA3PDPK1IDO1CHRNB2 | |
| SCHEMBL23797352 | 0.85 | CHRNB4 (0.59) | CHRNB4CHRNA3PDPK1IDO1CHRNB2 | |
| SCHEMBL11704162 | 0.80 | CHRNB4 (0.54) | CHRNB4CHRNA3PDPK1NOS1 | |
| SCHEMBL11701290 | 0.78 | CHRNB4 (0.52) | CHRNB4CHRNA3NOS1SLC18A3 | |
| SCHEMBL11704954 | 0.78 | CHRNB4 (0.52) | CHRNB4CHRNA3NOS1SLC18A3 | |
| SCHEMBL2913620 | 0.78 | CHRNB4 (0.44) | CHRNB4CHRNA3PDPK1IDO1NOS3 | |
| SCHEMBL6940509 | 0.74 | CHRNB4 (0.50) | CHRNB4CHRNA3PDPK1IDO1CHRNB2 | |
| SCHEMBL3425103 | 0.74 | CHRNB4 (0.50) | CHRNB4CHRNA3PDPK1IDO1CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968280-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |