Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 7/20 | 0.35 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16099890 | 1.00 | RXRA (0.38) | RXRARXRBRXRGHTR3AELANE | |
| SCHEMBL16100137 | 0.84 | RXRA (0.37) | RXRARXRBRXRGATRPLA2G2A | |
| SCHEMBL16100139 | 0.84 | RXRA (0.37) | RXRARXRBRXRGATRPLA2G2A | |
| SCHEMBL14792743 | 0.84 | RXRA (0.39) | RXRARXRBRXRGELANEATR | |
| SCHEMBL6502931 | 0.84 | ELANE (0.51) | RXRARXRBRXRGELANEATR | |
| SCHEMBL29593200 | 0.84 | ELANE (0.51) | RXRARXRBRXRGELANEATR | |
| SCHEMBL298676 | 0.83 | CYP4F2 (0.36) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL16100337 | 0.83 | CYP4F2 (0.36) | RXRARXRBRXRGATRCYP4F2 | |
| SCHEMBL16125889 | 0.83 | ELANE (0.41) | RXRARXRBRXRGELANEATR | |
| SCHEMBL31005998 | 0.83 | RXRA (0.39) | RXRARXRBRXRGELANEATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970220-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014153235-A2 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |