SCHEMBL6502931

SCHEMBL6502931

COC(=O)c1nn(C2CCCCO2)c2ccc(Br)cc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 0.51
RXRA P19793 1/20 0.39
RXRB P28702 1/20 0.39
RXRG P48443 1/20 0.39
MAPK8 P45983 1/20 0.38
ATR Q13535 1/20 0.37
CNR2 P34972 1/20 0.36
MAPT P10636 2/20 0.36
HTT P42858 2/20 0.36
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
TP53 P04637 1/20 0.36
MAPK1 P28482 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
POLB P06746 1/20 0.36
CDK1 P06493 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29593200 1.00 ELANE (0.51) ELANERXRARXRBRXRGMAPK8
SCHEMBL16125889 0.88 ELANE (0.41) ELANERXRARXRBRXRGATR
SCHEMBL31005998 0.88 RXRA (0.39) ELANERXRARXRBRXRGATR
SCHEMBL18823955 0.88 HTR3A (0.40) ELANERXRARXRBRXRGATR
SCHEMBL14792743 0.87 RXRA (0.39) ELANERXRARXRBRXRGATR
SCHEMBL16881036 0.87 CNR2 (0.39) ELANERXRARXRBRXRGATR
SCHEMBL6507201 0.86 RXRA (0.41) ELANERXRARXRBRXRGMAPK8
SCHEMBL29121783 0.85 ELANE (0.56) ELANEMAPK8HTTTP53POLB
SCHEMBL31006023 0.84 ELANE (0.53) ELANERXRARXRBRXRGCNR2
SCHEMBL31078730 0.84 ATR (0.37) ELANERXRARXRBRXRGATR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12558341-B2 Oral complement factor D inhibitors BIOCRYST PHARMACEUTICALS, INC. (US) 2026-02-24 US disclosed
EP-4665733-A1 AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 Bristol-Myers Squibb Company (US) 2025-12-24 EP disclosed
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 US disclosed
WO-2024173323-A1 AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-22 WO disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 US disclosed
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-07-18 US disclosed
US-20240132464-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS ACCUTAR BIOTECHNOLOGY INC. (US) 2024-04-25 US disclosed
WO-2024073502-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS ACCUTAR BIOTECHNOLOGY INC. (US) 2024-04-04 WO disclosed
CN-117120419-A KLK5 bicyclic heteroaromatic inhibitors 拜奥克里斯特制药公司 2023-11-24 CN disclosed
US-11780823-B2 Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors BIOSPLICE THERAPEUTICS, INC. (US) 2023-10-10 US disclosed
US-8697887-B2 Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors SAMUMED, LLC (US) 2014-04-15 US disclosed
US-20140045815-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/BETA-CATENIN SIGNALING PATHWAY INHIBITORS SAMUMED, LLC (US) 2014-02-13 US disclosed
US-20140045815-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/BETA-CATENIN SIGNALING PATHWAY INHIBITORS SAMUMED, LLC (US) 2014-02-13 US disclosed
US-20140045815-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/BETA-CATENIN SIGNALING PATHWAY INHIBITORS SAMUMED, LLC (US) 2014-02-13 US disclosed
US-20130079329-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2013-03-28 US disclosed
US-20130079329-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2013-03-28 US disclosed
US-20130079329-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS VICKERS VENTURE FUND VI (PLAN) PTE. LTD. (SG) 2013-03-28 US disclosed
WO-2013040215-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS SAMUMED, LLC (US) 2013-03-21 WO disclosed
WO-2013040215-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS SAMUMED, LLC (US) 2013-03-21 WO disclosed
US-20050090529-A1 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation PFIZER INC 2005-04-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239752-A1 BICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 KLK5, KLK1, KLKB1 ELANE 110/4885RXRA 3326/4885RXRB 2993/4885
US-20140045815-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/BETA-CATENIN SIGNALING PATHWAY INHIBITORS WNT3, WNT1, WNT3A ELANE 3821/4885RXRA 2508/4885RXRB 2334/4885
US-12558341-B2 Oral complement factor D inhibitors CFD, CFH, CFB ELANE 60/4885RXRA 3640/4885RXRB 3346/4885
US-20050090529-A1 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation CDK3, CDK4, CDK9 ELANE 3200/4885RXRA 2748/4885RXRB 2441/4885
US-20240132464-A1 HETEROCYCLIC COMPOUNDS AS E3 LIGASE INHIBITORS GID4, MDM2, XIAP ELANE 3819/4885RXRA 4228/4885RXRB 3939/4885
US-20130079329-A1 INDAZOLE-3-CARBOXAMIDES AND THEIR USE AS WNT/Beta-CATENIN SIGNALING PATHWAY INHIBITORS WNT3, WNT1, WNT3A ELANE 3821/4885RXRA 2508/4885RXRB 2334/4885
US-11780823-B2 Indazole-3-carboxamides and their use as Wnt/β-catenin signaling pathway inhibitors WNT1, WNT3, WNT3A ELANE 3940/4885RXRA 2341/4885RXRB 2211/4885
US-20250186391-A1 ORAL COMPLEMENT FACTOR D INHIBITORS CFD, CFH, CFB ELANE 76/4885RXRA 4205/4885RXRB 4075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.