Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | CES1 | P23141 | 2/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL28493361 | 1.00 | CA1 (0.57) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL27623918 | 0.98 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL407205 | 0.98 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL6681729 | 0.98 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL407206 | 0.91 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL16554130 | 0.91 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL9684585 | 0.91 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL17512809 | 0.91 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL29806213 | 0.91 | CES1 (0.58) | CA1CA2CES1PTGS2PTGS1 | |
| P-Nitrophenol SCHEMBL11048842 | 0.91 | CES1 (0.58) | CA1CA2CES1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1981 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115096882-B | Alkaline phosphatase detection kit and preparation method thereof | 北京安图生物工程有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-117512059-A | Alkaline phosphatase detection kit | 北京安图生物工程有限公司 | 2024-02-06 | — | — | CN | claimed |
| CN-115932274-A | Parkinson disease diagnosis or auxiliary diagnosis kit | 苏州百脉得生物科技有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-115160282-A | Citrinin hapten, preparation method thereof, artificial antigen, enzyme linked immunosorbent assay kit and detection method | 国家食品安全风险评估中心 | 2022-10-11 | — | — | CN | claimed |
| CN-115096882-A | Alkaline phosphatase detection kit and preparation method thereof | 北京安图生物工程有限公司 | 2022-09-23 | — | — | CN | claimed |
| CN-113720831-A | Device capable of identifying target object in real time and real-time target object identification method | 德路通（石家庄）生物科技有限公司 | 2021-11-30 | — | — | CN | claimed |
| CN-108828205-B | Ochratoxin A hapten, artificial antigen, preparation method and kit of artificial antigen, and ochratoxin A detection method | 国家食品安全风险评估中心 | 2021-11-02 | — | — | CN | claimed |
| CN-106432434-B | Foot-and-mouth disease A type structural protein VP1 antibody enzyme-linked immunoassay kit | 中牧实业股份有限公司 | 2019-11-12 | — | — | CN | claimed |
| CN-109485703-A | A kind of foot-and-mouth disease a type Structural protein VP1 antigen epitope polypeptide and its application | 中牧实业股份有限公司 | 2019-03-19 | — | — | CN | claimed |
| CN-108828205-A | Ochratoxin A haptens, artificial antigen and preparation method thereof, kit and ochratoxin A detection method | 国家食品安全风险评估中心 | 2018-11-16 | — | — | CN | claimed |
| WO-2003018854-A2 | IMMOBILIZATION OF BIOLOGICAL MOLECULES ONTO SURFACES COATED WITH MONOLAYERS | SURFACE LOGIX, INC. (US) | 2003-03-06 | — | — | WO | claimed |
| EP-0642587-A4 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA. | UNIV MICHIGAN (US) | 1997-03-19 | — | — | EP | claimed |
| EP-0642587-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | THE UNIVERSITY OF MICHIGAN (US) | 1995-03-15 | — | — | EP | claimed |
| US-5306621-A | Enhanced chemiluminescent assay | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1994-04-26 | — | — | US | claimed |
| WO-1993024651-A1 | SYSTEM FOR MEASURING PROTEOLYTIC ACTIVITY OF PERIODONTOPATHOGENIC BACTERIA | UNIVERSITY OF MICHIGAN (US) | 1993-12-09 | — | — | WO | claimed |
| US-5202232-A | Immunological testing | THE ROCKEFELLER UNIVERSITY (US) | 1993-04-13 | — | — | US | claimed |
| EP-0127681-B1 | IGA BINDING PROTEIN | THE ROCKEFELLER UNIVERSITY (US) | 1993-03-03 | — | — | EP | claimed |
| US-5116735-A | Colorimetric assay, hydrolysis of chromogen | THE UNIVERSITY OF MICHIGAN (US) | 1992-05-26 | — | — | US | claimed |
| US-4162194-A | DEETHERIFICATION, PHOSPHORYLATION AND TRANSPHOSPHORYLATION | BECKMAN INSTRUMENTS, INC. (US) | 1979-07-24 | — | — | US | claimed |
| US-4132598-A | Stabilized liquid phosphate containing diagnostic compositions and method of preparing same | MEDICAL ANALYSIS SYSTEMS, INC. | 1979-01-02 | — | — | US | claimed |