Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL5691090 | 0.98 | CA1 (0.52) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL6681724 | 0.94 | CA1 (0.50) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL28493361 | 0.91 | CA1 (0.57) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL161007 | 0.91 | CA1 (0.57) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL27623918 | 0.89 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL407205 | 0.89 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL6681729 | 0.89 | CA1 (0.55) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL2057329 | 0.89 | CA1 (0.58) | CA1CA2CES1PTGS1PTGS2 | |
| P-Nitrophenol SCHEMBL9684585 | 0.88 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 | |
| P-Nitrophenol SCHEMBL17512809 | 0.88 | CA1 (0.53) | CA1CA2CES1CES2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117399072-A | Ultra-small cerium-based metal organic framework nano enzyme and preparation method and application thereof | 华南理工大学 | 2024-01-16 | — | — | CN | claimed |
| CN-108717076-B | Electrochemical biosensor for detecting zeatin and preparation method thereof | 山东农业大学 | 2019-12-24 | — | — | CN | claimed |
| CN-102384902-B | Enzyme chip based on quantum dot fluorescence detection and preparation method and application thereof | CHINESE ACAD TECH INST PHYSICS | 2013-03-20 | — | — | CN | claimed |
| CN-102081040-B | Method for detecting enzyme activity by quantum dot fluorescence | CHINESE ACAD TECH INST PHYSICS | 2012-05-30 | — | — | CN | claimed |
| CN-102384902-A | Enzyme chip based on quantum dot fluorescence detection and preparation method and application thereof | CHINESE ACAD TECH INST PHYSICS | 2012-03-21 | — | — | CN | claimed |
| CN-102081040-A | Method for detecting enzyme activity by quantum dot fluorescence | CHINESE ACAD TECH INST PHYSICS | 2011-06-01 | — | — | CN | claimed |
| CN-122070150-A | Composition containing BMP-2, and preparation method and application thereof | 杭州九源基因生物医药股份有限公司 | 2026-05-19 | — | — | CN | disclosed |
| EP-3473706-B1 | CELL-EMBEDDED BEADS FOR HAIR REGENERATION AND METHOD FOR PRODUCING SAME, AND KIT FOR HAIR REGENERATION | NAT UNIV CORP YOKOHAMA NAT UNIV (JP) | 2025-09-10 | — | — | EP | disclosed |
| CN-117965529-B | Cell lysate, enzyme activity detection kit in cells and application | 伊莱瑞特(武汉)生物技术有限公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-119950495-A | Use of compound for interfering integrin beta 3/Src interaction | 上海交通大学医学院附属瑞金医院 | 2025-05-09 | — | — | CN | disclosed |
| CN-113967210-B | Use of compound for interfering integrin beta 3/Src interaction | 上海交通大学医学院附属瑞金医院 | 2025-02-07 | — | — | CN | disclosed |
| CN-117965529-A | Cell lysate, enzyme activity detection kit in cells and application | 伊莱瑞特(武汉)生物技术有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117399072-A | Ultra-small cerium-based metal organic framework nano enzyme and preparation method and application thereof | 华南理工大学 | 2024-01-16 | — | — | CN | disclosed |
| WO-1996012189-A2 | METHODS OF SCREENING FOR ULCERATIVE COLITIS AND CROHN'S DISEASE BY DETECTING VH3-15 AUTOANTIBODY AND pANCA | CEDARS-SINAI MEDICAL CENTER (US) | 1996-04-25 | — | — | WO | disclosed |
| EP-0615129-A2 | Methods for selectively detecting perinuclear anti-neutrophilcytoplasmic antibody of ulcerative colitis or primary sclerosing cholangitis | Cedars-Sinai Medical Center (US) | 1994-09-14 | — | — | EP | disclosed |
| WO-1992002819-A2 | ASSAY FOR ULCERATIVE COLITIS AND PRIMARY SCLEROSING CHOLANGITIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-02-20 | — | — | WO | disclosed |
| EP-0182179-B1 | INTEGRAL MULTILAYER ANALYTICAL ELEMENT FOR USE IN THE MEASUREMENT OF ALKALINE PHOSPHATASE ACITIVITY | FUJI PHOTO FILM CO., LTD. (JP) | 1989-10-18 | — | — | EP | disclosed |
| US-4797476-A | Mono-4-arylazoaryl phosphoric esters | FUJI SHASHIN FILM KABUSHIKI KAISHA (JP) | 1989-01-10 | — | — | US | disclosed |
| EP-0182179-A1 | Integral multilayer analytical element for use in the measurement of alkaline phosphatase acitivity | FUJI PHOTO FILM CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| EP-0061731-A2 | Novel phosphoric ester and a method for quantitative analysis of an alkaline phosphatase using the same as a substrate | Fuji Photo Film Co., Ltd. (JP) | 1982-10-06 | — | — | EP | disclosed |