Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23763044 | 0.91 | LRRK2 (0.41) | LRRK2NAMPTMKNK1MKNK2HCRTR1 | |
| SCHEMBL18706528 | 0.84 | PIM1 (0.39) | LRRK2ACHEPSMB8PSMB9MKNK1 | |
| SCHEMBL20916371 | 0.82 | ACHE (0.44) | LRRK2ACHEPSMB8PSMB9HCRTR1 | |
| SCHEMBL874829 | 0.82 | ACHE (0.47) | LRRK2ACHEPSMB8PSMB9HCRTR1 | |
| SCHEMBL16101793 | 0.81 | LRRK2 (0.39) | LRRK2ACHEPSMB8PSMB9MKNK1 | |
| SCHEMBL15703080 | 0.80 | OGA (0.39) | LRRK2ACHENAMPTMKNK1MKNK2 | |
| SCHEMBL22031498 | 0.79 | ACHE (0.39) | ACHEPSMB8PSMB9HCRTR1HCRTR2 | |
| SCHEMBL22585673 | 0.78 | LRRK2 (0.40) | LRRK2ACHEPSMB8PSMB9PIM1 | |
| SCHEMBL27120216 | 0.77 | LRRK2 (0.34) | LRRK2ACHENAMPTMKNK1MKNK2 | |
| SCHEMBL15652587 | 0.77 | BMPR1A (0.37) | LRRK2ACHENAMPTMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970211-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals Inc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151106-A1 | HISTONE DEMETHYLASE INHIBITORS | Quanticel Pharmaceuticals, Inc. (US) | 2014-09-25 | — | — | WO | disclosed |