Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 6/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16096743 | 0.84 | CHKA (1.00) | CHKANCF1CA2PRMT6KDM4E | |
| SCHEMBL16096094 | 0.84 | CHKA (0.72) | CHKAL3MBTL1GAAPOLBNCF1 | |
| SCHEMBL16121999 | 0.80 | CHKA (0.77) | CHKANCF1CA2PRMT6KDM4E | |
| SCHEMBL3063745 | 0.80 | GAA (0.70) | L3MBTL1GAAPOLBNCF1KDM4E | |
| SCHEMBL1723129 | 0.80 | L3MBTL1 (0.85) | L3MBTL1GAAPOLBMAPTALOX15 | |
| SCHEMBL30855058 | 0.79 | GAA (0.60) | L3MBTL1GAAPOLBNCF1KDM4E | |
| SCHEMBL16095017 | 0.79 | CHKA (0.74) | CHKAPOLBNCF1CA2PRMT6 | |
| SCHEMBL16121802 | 0.77 | CHKA (0.72) | CHKANCF1CA2PRMT6KDM4E | |
| SCHEMBL2462363 | 0.77 | L3MBTL1 (1.00) | L3MBTL1GAAPOLBKDM4EMAPT | |
| SCHEMBL30855008 | 0.77 | MAPT (0.63) | L3MBTL1GAANCF1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834521-B2 | Choline kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834521-B2 | Choline kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-9834521-B2 | Choline kinase inhibitors | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20160024024-A1 | Novel Choline Kinase Inhibitors | ARIAD PHARMACEUTICALS, INC. | 2016-01-28 | — | — | US | disclosed |
| US-20160024024-A1 | Novel Choline Kinase Inhibitors | ARIAD PHARMACEUTICALS, INC. | 2016-01-28 | — | — | US | disclosed |
| US-20160024024-A1 | Novel Choline Kinase Inhibitors | ARIAD PHARMACEUTICALS, INC. | 2016-01-28 | — | — | US | disclosed |
| EP-2968358-A1 | NOVEL CHOLINE KINASE INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151761-A1 | NOVEL CHOLINE KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014151761-A1 | NOVEL CHOLINE KINASE INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024024-A1 | Novel Choline Kinase Inhibitors | CHKA, CHKB, CEPT1 | CHKA 1/4885L3MBTL1 3814/4885GAA 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.